• Gene id: 50506

Gene Summary

• Gene Symbol: DUOX2   Gene   UCSC   Ensembl
• Aliases: LNOX2, NOXEF2, P138-TOX, TDH6, THOX2
• Gene name: dual oxidase 2
• Alternate names: dual oxidase 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, dual oxidase-like domains 2, flavoprotein NADPH oxidase, large NOX 2, long NOX 2, nicotinamide adenine dinucleotide phosphate oxidase, p138 thyroid oxidas,
• Gene location: 15q21.1 (45114171: 45092649)     Exons: 34     NC_000015.10
• Gene summary(Entrez): The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide tra
• OMIM: 605379

Protein Summary

• Protein general information: Q9NRD8  
  • Name: Dual oxidase 2 (EC 1.11.1. ) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138 tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase)
  • Length: 1548  
  • Mass: 175364
  • Tissue specificity: Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. {ECO
• Sequence:

  MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEE
  PQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVL
  PFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAP
  DPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE
  WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWI
  RENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGL
  DIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNG
  LFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI
  TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVL
  NRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMS
  EKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVE
  SMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL
  AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERS
  HPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSA
  ICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVD
  FHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA
  IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVV
  KAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSP
  KGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQ
  FEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN
  SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

• Structural information:
  • Protein Domains: (819..85-)
    (/note="EF-hand-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (855..89-)
    (/note="EF-hand-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (899..93-)
    (/note="EF-hand-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR034818  IPR034821  IPR011992  IPR018247  IPR002048   IPR013112  IPR017927  IPR013130  IPR013121  IPR039261  IPR019791  IPR010255  IPR037120  IPR017938  
  • Prosite: PS00018 PS50222 PS51384 PS50292
  • CDD: cd09820 cd00051
  • STRING: ENSP00000475084
• Other Databases: GeneCards:  DUOX2  Malacards:  DUOX2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IMP	molecular function
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0042554	superoxide anion generation	IBA	biological process
GO:0006952	defense response	IBA	biological process
GO:0043020	NADPH oxidase complex	IBA	cellular component
GO:0016175	superoxide-generating NADPH oxidase activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0004601	peroxidase activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IEA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0050665	hydrogen peroxide biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0006979	response to oxidative stress	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0004601	peroxidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0042446	hormone biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0042744	hydrogen peroxide catabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0006590	thyroid hormone generation	TAS	biological process
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0006590	thyroid hormone generation	IEA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0019221	cytokine-mediated signaling pathway	IDA	biological process
GO:0009615	response to virus	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0045177	apical part of cell	IDA	cellular component
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IDA	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0051591	response to cAMP	IDA	biological process
GO:0031252	cell leading edge	IGI	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042335	cuticle development	ISS	biological process
GO:2000147	positive regulation of cell motility	IGI	biological process
GO:0042554	superoxide anion generation	IGI	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0019221	cytokine-mediated signaling pathway	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IGI	cellular component
GO:0051591	response to cAMP	ISS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0055114	oxidation-reduction process	TAS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0009986	cell surface	IGI	cellular component
GO:0009986	cell surface	IGI	cellular component
GO:0090303	positive regulation of wound healing	IGI	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0005886	plasma membrane	IGI	cellular component
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IMP	molecular function
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0042554	superoxide anion generation	IBA	biological process
GO:0006952	defense response	IBA	biological process
GO:0043020	NADPH oxidase complex	IBA	cellular component
GO:0016175	superoxide-generating NADPH oxidase activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0004601	peroxidase activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IEA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0050665	hydrogen peroxide biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0006979	response to oxidative stress	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0004601	peroxidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0042446	hormone biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0042744	hydrogen peroxide catabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0006590	thyroid hormone generation	TAS	biological process
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0006590	thyroid hormone generation	IEA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0019221	cytokine-mediated signaling pathway	IDA	biological process
GO:0009615	response to virus	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0045177	apical part of cell	IDA	cellular component
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IDA	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0051591	response to cAMP	IDA	biological process
GO:0031252	cell leading edge	IGI	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042335	cuticle development	ISS	biological process
GO:2000147	positive regulation of cell motility	IGI	biological process
GO:0042554	superoxide anion generation	IGI	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0019221	cytokine-mediated signaling pathway	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IGI	cellular component
GO:0051591	response to cAMP	ISS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0055114	oxidation-reduction process	TAS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0009986	cell surface	IGI	cellular component
GO:0009986	cell surface	IGI	cellular component
GO:0090303	positive regulation of wound healing	IGI	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IGI	biological process
GO:0005886	plasma membrane	IGI	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04918	Thyroid hormone synthesis

Diseases

Associated diseases	References
Thyroid dyshormonogenesis	KEGG:H00251
Thyroid dyshormonogenesis	KEGG:H00251
Congenital hypothyroidism	PMID:12110737
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881