• Gene id: 50487

Gene Summary

• Gene Symbol: PLA2G3   Gene   UCSC   Ensembl
• Aliases: GIII-SPLA2, SPLA2III, sPLA2-III
• Gene name: phospholipase A2 group III
• Alternate names: group 3 secretory phospholipase A2, group III secreted phospholipase A2, phosphatidylcholine 2-acylhydrolase 3, phosphatidylcholine 2-acylhydrolase GIII,
• Gene location: 22q12.2 (110118138: 110083869)     Exons: 5     NC_000002.12
• Gene summary(Entrez): This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phosphol
• OMIM: 611651

Protein Summary

• Protein general information: Q9NZ20  
  • Name: Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2 III) (Phosphatidylcholine 2 acylhydrolase 3)
  • Length: 509  
  • Mass: 57167
  • Tissue specificity: Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and al
• Sequence:

  MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWED
  EPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRG
  WTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQH
  DSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPP
  KPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQI
  GPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVS
  ARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ

• Structural information:
  • Interpro: IPR016090  IPR036444  IPR033113  
  • Prosite: PS00118
  • STRING: ENSP00000215885
• Other Databases: GeneCards:  PLA2G3  Malacards:  PLA2G3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046473	phosphatidic acid metabolic process	IDA	biological process
GO:0046488	phosphatidylinositol metabolic process	IDA	biological process
GO:0046337	phosphatidylethanolamine metabolic process	IDA	biological process
GO:0046470	phosphatidylcholine metabolic process	IDA	biological process
GO:0031394	positive regulation of prostaglandin biosynthetic process	IDA	biological process
GO:0055037	recycling endosome	IDA	cellular component
GO:0010744	positive regulation of macrophage derived foam cell differentiation	IDA	biological process
GO:0034375	high-density lipoprotein particle remodeling	IDA	biological process
GO:0006658	phosphatidylserine metabolic process	IDA	biological process
GO:0046471	phosphatidylglycerol metabolic process	IDA	biological process
GO:0047498	calcium-dependent phospholipase A2 activity	IDA	molecular function
GO:0047498	calcium-dependent phospholipase A2 activity	IDA	molecular function
GO:1903595	positive regulation of histamine secretion by mast cell	IDA	biological process
GO:0034374	low-density lipoprotein particle remodeling	IDA	biological process
GO:0047498	calcium-dependent phospholipase A2 activity	IDA	molecular function
GO:0005814	centriole	IDA	cellular component
GO:0060271	cilium assembly	IMP	biological process
GO:0043524	negative regulation of neuron apoptotic process	IMP	biological process
GO:0010976	positive regulation of neuron projection development	IMP	biological process
GO:2001135	regulation of endocytic recycling	IMP	biological process
GO:0006644	phospholipid metabolic process	IEA	biological process
GO:0004623	phospholipase A2 activity	IEA	molecular function
GO:0050482	arachidonic acid secretion	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0030030	cell projection organization	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016042	lipid catabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0047498	calcium-dependent phospholipase A2 activity	TAS	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0006644	phospholipid metabolic process	TAS	biological process
GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	IEA	molecular function
GO:0004623	phospholipase A2 activity	IEA	molecular function
GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	IEA	molecular function
GO:0036148	phosphatidylglycerol acyl-chain remodeling	TAS	biological process
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	biological process
GO:0001675	acrosome assembly	IEA	biological process
GO:0048468	cell development	IEA	biological process
GO:0007288	sperm axoneme assembly	IEA	biological process
GO:0019372	lipoxygenase pathway	IEA	biological process
GO:0043303	mast cell degranulation	IEA	biological process
GO:0046470	phosphatidylcholine metabolic process	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005814	centriole	IEA	cellular component
GO:0042629	mast cell granule	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04014	Ras signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa00564	Glycerophospholipid metabolism
hsa04972	Pancreatic secretion
hsa00590	Arachidonic acid metabolism
hsa00565	Ether lipid metabolism
hsa04975	Fat digestion and absorption
hsa00591	Linoleic acid metabolism
hsa00592	alpha-Linolenic acid metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)