• Gene id: 5005

Gene Summary

• Gene Symbol: ORM2   Gene   UCSC   Ensembl
• Aliases: AGP-B, AGP-B', AGP2
• Gene name: orosomucoid 2
• Alternate names: alpha-1-acid glycoprotein 2, AGP 2, OMD 2, alpha-1-acid glycoprotein, type 2,
• Gene location: 9q32 (114329868: 114333250)     Exons: 6     NC_000009.12
• Gene summary(Entrez): This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved
• OMIM: 138610

Protein Summary

• Protein general information: P19652  
  • Name: Alpha 1 acid glycoprotein 2 (AGP 2) (Orosomucoid 2) (OMD 2)
  • Length: 201  
  • Mass: 23603
  • Tissue specificity: Expressed by the liver and secreted in plasma.
• Sequence:

  MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTE
  DTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPE
  TTKEQLGEFYEALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES

• Structural information:
  • Interpro: IPR001500  IPR012674  IPR000566  
  • PDB: 3APU 3APV 3APW 3APX
  • PDBsum: 3APU 3APV 3APW 3APX
  • STRING: ENSP00000394936
• Other Databases: GeneCards:  ORM2  Malacards:  ORM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0002682	regulation of immune system process	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006953	acute-phase response	IEA	biological process
GO:0006953	acute-phase response	TAS	biological process
GO:0005615	extracellular space	TAS	cellular component
GO:0002576	platelet degranulation	TAS	biological process
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0035578	azurophil granule lumen	TAS	cellular component
GO:0035580	specific granule lumen	TAS	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0050716	positive regulation of interleukin-1 secretion	IDA	biological process
GO:1904469	positive regulation of tumor necrosis factor secretion	IDA	biological process
GO:0050718	positive regulation of interleukin-1 beta secretion	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0072562	blood microparticle	HDA	cellular component
GO:0005615	extracellular space	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray