• Gene id: 497189

Gene Summary

• Gene Symbol: TIFAB   Gene   UCSC   Ensembl
• Gene name: TIFA inhibitor
• Alternate names: TRAF-interacting protein with FHA domain-containing protein B, TIFA-like protein, TIFA-related protein TIFAB, TRAF-interacting protein with forkhead-associated domain, family member B,
• Gene location: 5q31.1 (135452350: 135444225)     Exons: 2     NC_000005.10
• Gene summary(Entrez): TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]
• OMIM: 612663

Protein Summary

• Protein general information: Q6ZNK6  
  • Name: TRAF interacting protein with FHA domain containing protein B (TIFA like protein)
  • Length: 161  
  • Mass: 17888
• Sequence:

  MEKPLTVLRVSLYHPTLGPSAFANVPPRLQHDTSPLLLGRGQDAHLQLQLPRLSRRHLSLEPYLEKGSALLAFCL
  KALSRKGCVWVNGLTLRYLEQVPLSTVNRVSFSGIQMLVRVEEGTSLEAFVCYFHVSPSPLIYRPEAEETDEWEG
  ISQGQPPPGSG

• Structural information:
  • Protein Domains: (36..9-)
    (/note="FHA-)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR000253  IPR008984  IPR033621  
  • CDD: cd00060
  • STRING: ENSP00000440509
• Other Databases: GeneCards:  TIFAB  Malacards:  TIFAB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007356	thorax and anterior abdomen determination	IGI	biological process
GO:0035112	genitalia morphogenesis	IGI	biological process
GO:1901078	negative regulation of relaxation of muscle	IGI	biological process
GO:0042472	inner ear morphogenesis	IGI	biological process
GO:0098583	learned vocalization behavior	IGI	biological process
GO:1905747	negative regulation of saliva secretion	IGI	biological process
GO:1905748	hard palate morphogenesis	IGI	biological process
GO:0021559	trigeminal nerve development	IGI	biological process
GO:0048806	genitalia development	IGI	biological process
GO:0021650	vestibulocochlear nerve formation	IGI	biological process
GO:0031223	auditory behavior	IGI	biological process
GO:0048634	regulation of muscle organ development	IGI	biological process
GO:0050885	neuromuscular process controlling balance	IGI	biological process
GO:0030432	peristalsis	IGI	biological process
GO:0071626	mastication	IGI	biological process
GO:0097094	craniofacial suture morphogenesis	IGI	biological process
GO:0048839	inner ear development	IGI	biological process
GO:0090102	cochlea development	IGI	biological process
GO:0090103	cochlea morphogenesis	IGI	biological process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq