• Gene id: 4958

Gene Summary

• Gene Symbol: OMD   Gene   UCSC   Ensembl
• Aliases: OSAD, SLRR2C
• Gene name: osteomodulin
• Alternate names: osteomodulin, KSPG osteomodulin, keratan sulfate proteoglycan osteomodulin, osteoadherin proteoglycan,
• Gene location: 9q22.31 (92424553: 92414244)     Exons: 3     NC_000009.12

Protein Summary

• Protein general information: Q99983  
  • Name: Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD)
  • Length: 421  
  • Mass: 49492
  • Tissue specificity: Bone specific.
• Sequence:

  MGFLSPIYVIFFFFGVKVHCQYETYQWDEDYDQEPDDDYQTGFPFRQNVDYGVPFHQYTLGCVSECFCPTNFPSS
  MYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEH
  NNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLE
  SMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPR
  NLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQL
  KTQVFRRFPDDDDESEDHDDPDNAHESPEQEGAEGHFDLHYYENQE

• Structural information:
  • Protein Domains: (53..9-)
    (/note="LRRNT"-)
  • Interpro: IPR001611  IPR003591  IPR032675  IPR000372  IPR030705  
  • Prosite: PS51450
  • PDB: 5YQ5
  • PDBsum: 5YQ5
  • STRING: ENSP00000364700
• Other Databases: GeneCards:  OMD  Malacards:  OMD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0062023	collagen-containing extracellular matrix	IEA	cellular component
GO:0030500	regulation of bone mineralization	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0018146	keratan sulfate biosynthetic process	TAS	biological process
GO:0042340	keratan sulfate catabolic process	TAS	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R