• Gene id: 493911

Gene Summary

• Gene Symbol: PHOSPHO2   Gene   UCSC   Ensembl
• Gene name: phosphatase, orphan 2
• Alternate names: pyridoxal phosphate phosphatase PHOSPHO2,
• Gene location: 2q31.1 (169694453: 169701707)     Exons: 5     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q8TCD6  
  • Name: Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74)
  • Length: 241  
  • Mass: 27769
• Sequence:

  MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGVREHEMKRAVTSLPFT
  PGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDKVFTNPAAFNSNGHLTVENYHTHSCNRCPKN
  LCKKVVLIEFVDKQLQQGVNYTQIVYIGDGGNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVW
  SSGVDIISHLQFLIKD

• Structural information:
  • Interpro: IPR036412  IPR023214  IPR016965  IPR006384  
  • STRING: ENSP00000481046
• Other Databases: GeneCards:  PHOSPHO2  Malacards:  PHOSPHO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016791	phosphatase activity	IBA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0033883	pyridoxal phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00750	Vitamin B6 metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)