• Gene id: 4917

Gene Summary

• Gene Symbol: NTN3   Gene   UCSC   Ensembl
• Aliases: NTN2L
• Gene name: netrin 3
• Alternate names: netrin-3, Netrin-2, chicken, homolog of, like, netrin-2-like protein,
• Gene location: 16p13.3 (2471296: 2474144)     Exons: 6     NC_000016.10
• OMIM: 108733

Protein Summary

• Protein general information: O00634  
  • Name: Netrin 3 (Netrin 2 like protein)
  • Length: 580  
  • Mass: 61466
  • Tissue specificity: Spinal cord. {ECO
• Sequence:

  MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRACDASDPRRA
  HSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFF
  SSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLT
  RPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRA
  TARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD
  CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARG
  SYRISLKKFCKKDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRY
  LLLGGGPGAAAGGAGGRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA

• Structural information:
  • Protein Domains: (36..25-)
    (/note="Laminin-N-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00466-)
    (255..30-)
    1 (/note="Laminin-EGF-like)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00460-)
    (311..37-)
    2 (/note="Laminin-EGF-like)
    (/evidence="ECO:-)
  • Interpro: IPR002049  IPR008211  IPR038684  IPR001134  IPR018933   IPR008993  
  • Prosite: PS00022 PS01248 PS50027 PS51117 PS50189
  • STRING: ENSP00000293973
• Other Databases: GeneCards:  NTN3  Malacards:  NTN3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005604	basement membrane	IBA	cellular component
GO:0009887	animal organ morphogenesis	IBA	biological process
GO:0016358	dendrite development	IBA	biological process
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0008045	motor neuron axon guidance	IBA	biological process
GO:0009888	tissue development	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0007411	axon guidance	NAS	biological process
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq