• Gene id: 4835

Gene Summary

• Gene Symbol: NQO2   Gene   UCSC   Ensembl
• Aliases: DHQV, DIA6, NMOR2, QR2
• Gene name: N-ribosyldihydronicotinamide:quinone reductase 2
• Alternate names: ribosyldihydronicotinamide dehydrogenase [quinone], NAD(P)H dehydrogenase, quinone 2, NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2, NAD(P)H quinone dehydrogenase 2, NRH:quinone oxidoreductase 2, quinone reductase 2, ribosyldihydronicotinamide dehydrog,
• Gene location: 6p25.2 (2999815: 3019875)     Exons: 11     NC_000006.12
• Gene summary(Entrez): This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutati
• OMIM: 124095

Protein Summary

• Protein general information: P16083  
  • Name: Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)
  • Length: 231  
  • Mass: 25919
• Sequence:

  MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEA
  YKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTG
  GTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTA
  HWHFGQ

• Structural information:
  • Interpro: IPR003680  IPR029039  
  • PDB: 1QR2 1SG0 1XI2 1ZX1 2BZS 2QMY 2QMZ 2QR2 2QWX 2QX4 2QX6 2QX8 2QX9 3FW1 3G5M 3GAM 3NFR 3NHF 3NHJ 3NHK 3NHL 3NHP 3NHR 3NHS 3NHU 3NHW 3NHY 3O2N 3O73 3OVM 3OWH 3OWX 3OX1 3OX2 3OX3 3TE7 3TEM 3TZB 3UXE 3UXH 4FGJ 4FGK 4FGL 4GQI 4GR9 4QOD 4QOE 4QOF 4QOG 4QOH 4QOI 4QOJ 4U7F 4U7G 4U7H 4XDG 4XDH 4ZVK 4ZVL 4ZVM 4ZVN 5BUC 5LBT 5LB
  • PDBsum: 1QR2 1SG0 1XI2 1ZX1 2BZS 2QMY 2QMZ 2QR2 2QWX 2QX4 2QX6 2QX8 2QX9 3FW1 3G5M 3GAM 3NFR 3NHF 3NHJ 3NHK 3NHL 3NHP 3NHR 3NHS 3NHU 3NHW 3NHY 3O2N 3O73 3OVM 3OWH 3OWX 3OX1 3OX2 3OX3 3TE7 3TEM 3TZB 3UXE 3UXH 4FGJ 4FGK 4FGL 4GQI 4GR9 4QOD 4QOE 4QOF 4QOG 4QOH 4QOI 4QOJ 4U7F 4U7G 4U7H 4XDG 4XDH 4ZVK 4ZVL 4ZVM 4ZVN 5BUC 5LBT 5LB
  • DIP: 39704
  • STRING: ENSP00000369822
• Other Databases: GeneCards:  NQO2  Malacards:  NQO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006805	xenobiotic metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	IEA	biological process
GO:0007613	memory	IEA	biological process
GO:2000379	positive regulation of reactive oxygen species metabolic process	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0043525	positive regulation of neuron apoptotic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0022900	electron transport chain	IEA	biological process
GO:0022900	electron transport chain	IEA	biological process
GO:0001512	dihydronicotinamide riboside quinone reductase activity	IDA	molecular function
GO:0071949	FAD binding	IDA	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA	molecular function
GO:1904408	melatonin binding	IDA	molecular function
GO:1905594	resveratrol binding	IDA	molecular function
GO:0009055	electron transfer activity	IDA	molecular function
GO:0009055	electron transfer activity	IDA	molecular function
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0031404	chloride ion binding	IDA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Agranulocytosis	PMID:14617031
Parkinson's disease	PMID:18314446
Breast carcinoma	PMID:21351093
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881