• Gene id: 4830

Gene Summary

• Gene Symbol: NME1   Gene   UCSC   Ensembl
• Aliases: AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1
• Gene name: NME/NM23 nucleoside diphosphate kinase 1
• Alternate names: nucleoside diphosphate kinase A, NDP kinase A, epididymis secretory sperm binding protein, granzyme A-activated DNase, metastasis inhibition factor nm23, non-metastatic cells 1, protein (NM23A) expressed in, tumor metastatic process-associated protein,
• Gene location: 17q21.33 (51153558: 51162167)     Exons: 6     NC_000017.11
• Gene summary(Entrez): This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this
• OMIM: 613567

Protein Summary

• Protein general information: P15531  
  • Name: Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23 H1) (Tumor metastatic process associated protein)
  • Length: 152  
  • Mass: 17149
  • Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression
• Sequence:

  MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
  MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWI
  YE

• Structural information:
  • Interpro: IPR034907  IPR036850  IPR001564  IPR023005  
  • Prosite: PS00469
  • PDB: 1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
  • PDBsum: 1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
  • DIP: 39164
  • STRING: ENSP00000337060
• Other Databases: GeneCards:  NME1  Malacards:  NME1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050679	positive regulation of epithelial cell proliferation	IMP	biological process
GO:0006163	purine nucleotide metabolic process	IBA	biological process
GO:0004550	nucleoside diphosphate kinase activity	IBA	molecular function
GO:0006220	pyrimidine nucleotide metabolic process	IBA	biological process
GO:0042981	regulation of apoptotic process	IBA	biological process
GO:0006228	UTP biosynthetic process	IEA	biological process
GO:0006241	CTP biosynthetic process	IEA	biological process
GO:0004550	nucleoside diphosphate kinase activity	IEA	molecular function
GO:0006165	nucleoside diphosphate phosphorylation	IEA	biological process
GO:0006183	GTP biosynthetic process	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0009117	nucleotide metabolic process	IEA	biological process
GO:0016310	phosphorylation	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0006897	endocytosis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0004550	nucleoside diphosphate kinase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0015949	nucleobase-containing small molecule interconversion	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007595	lactation	IEA	biological process
GO:0071398	cellular response to fatty acid	IEA	biological process
GO:0071333	cellular response to glucose stimulus	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0035690	cellular response to drug	IEA	biological process
GO:0021766	hippocampus development	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005813	centrosome	IEA	cellular component
GO:0030879	mammary gland development	IEA	biological process
GO:0051591	response to cAMP	IEA	biological process
GO:0043015	gamma-tubulin binding	IEA	molecular function
GO:0042493	response to drug	IEA	biological process
GO:0033574	response to testosterone	IEA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0019215	intermediate filament binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0014075	response to amine	IEA	biological process
GO:0010976	positive regulation of neuron projection development	IEA	biological process
GO:0010629	negative regulation of gene expression	IEA	biological process
GO:0006165	nucleoside diphosphate phosphorylation	IEA	biological process
GO:0005882	intermediate filament	IEA	cellular component
GO:0005741	mitochondrial outer membrane	IEA	cellular component
GO:0004550	nucleoside diphosphate kinase activity	IEA	molecular function
GO:0003697	single-stranded DNA binding	IEA	molecular function
GO:0002762	negative regulation of myeloid leukocyte differentiation	IEA	biological process
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0006259	DNA metabolic process	IEA	biological process
GO:0043388	positive regulation of DNA binding	IDA	biological process
GO:0032587	ruffle membrane	IDA	cellular component
GO:0005525	GTP binding	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005524	ATP binding	IDA	molecular function
GO:0004550	nucleoside diphosphate kinase activity	IDA	molecular function
GO:0004536	deoxyribonuclease activity	IDA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0008285	negative regulation of cell population proliferation	TAS	biological process
GO:0005737	cytoplasm	TAS	cellular component
GO:0005634	nucleus	TAS	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0043024	ribosomal small subunit binding	IPI	molecular function
GO:0042981	regulation of apoptotic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism
hsa00983	Drug metabolism - other enzymes
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
Prostate cancer	PMID:8618340
urinary bladder cancer	PMID:7614395
Breast cancer	PMID:8605098
Squamous cell carcinoma	PMID:8978595
ovary epithelial cancer	PMID:7622307
Ovarian cancer	PMID:8519661
Ovarian cancer	PMID:8636741
Teratoma	PMID:7518576
Breast carcinoma	PMID:9036878
pancreatic ductal carcinoma	PMID:17492507
renal cell carcinoma	PMID:9663430
neuroblastoma	PMID:8047138
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881