• Gene id: 4798

Gene Summary

• Gene Symbol: NFRKB   Gene   UCSC   Ensembl
• Aliases: INO80G
• Gene name: nuclear factor related to kappaB binding protein
• Alternate names: nuclear factor related to kappa-B-binding protein, DNA-binding protein R kappa B, INO80 complex subunit G,
• Gene location: 11q24.3 (129895595: 129863635)     Exons: 8     NC_000011.10
• OMIM: 164013

Protein Summary

• Protein general information: Q6P4R8  
  • Name: Nuclear factor related to kappa B binding protein (DNA binding protein R kappa B) (INO80 complex subunit G)
  • Length: 1299  
  • Mass: 139001
  • Tissue specificity: Expressed in thymus, brain, testes, spleen and liver. {ECO
• Sequence:

  MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLP
  QFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQI
  LASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPAR
  SPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLA
  ALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEI
  SSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVE
  FKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQE
  RYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEI
  CELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKA
  LQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPST
  VSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQ
  TLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTS
  APSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPD
  MMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKP
  TEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVH
  TSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSV
  VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTAS
  GSSKAVSTVVVTTAPSPKQAPEQQ

• Structural information:
  • Interpro: IPR024867  IPR025220  IPR038106  
  • PDB: 3U21 4UF5 4UF6 4WLP
  • PDBsum: 3U21 4UF5 4UF6 4WLP
  • STRING: ENSP00000436926
• Other Databases: GeneCards:  NFRKB  Malacards:  NFRKB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002020	protease binding	IBA	molecular function
GO:0031011	Ino80 complex	IBA	colocalizes with
GO:0031011	Ino80 complex	IDA	cellular component
GO:0031011	Ino80 complex	IDA	colocalizes with
GO:0005634	nucleus	IDA	cellular component
GO:0002020	protease binding	IPI	molecular function
GO:0031011	Ino80 complex	IEA	cellular component
GO:0006281	DNA repair	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0006310	DNA recombination	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0006954	inflammatory response	TAS	biological process
GO:0006366	transcription by RNA polymerase II	TAS	biological process
GO:0016579	protein deubiquitination	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq