• Gene id: 4685

Gene Summary

• Gene Symbol: NCAM2   Gene   UCSC   Ensembl
• Aliases: NCAM21
• Gene name: neural cell adhesion molecule 2
• Alternate names: neural cell adhesion molecule 2, N-CAM-2, NCAM-2,
• Gene location: 21q21.1 (20998338: 21543328)     Exons: 26     NC_000021.9
• Gene summary(Entrez): The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
• OMIM: 602040

Protein Summary

• Protein general information: O15394  
  • Name: Neural cell adhesion molecule 2 (N CAM 2) (NCAM 2)
  • Length: 837  
  • Mass: 93046
  • Tissue specificity: Expressed most strongly in adult and fetal brain.
• Sequence:

  MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVR
  SRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLY
  HNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERG
  EEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
  QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS
  GRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLK
  TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGV
  PIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
  GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYS
  EPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKS
  KELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSN
  DIIQSKEDDSKA

• Structural information:
  • Protein Domains: (21..10-)
    1 (/note="Ig-like-C2-type)
    (113..20-)
    2 (/note="Ig-like-C2-type)
    (208..29-)
    3 (/note="Ig-like-C2-type)
    (302..39-)
    4 (/note="Ig-like-C2-type)
    (401..49-)
    5 (/note="Ig-like-C2-type)
    (498..59-)
    (/note="Fibron-)
  • Interpro: IPR003961  IPR036116  IPR007110  IPR036179  IPR013783   IPR013098  IPR003599  IPR003598  IPR013106  IPR009138  
  • Prosite: PS50853 PS50835
  • CDD: cd00063
  • PDB: 2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC
  • PDBsum: 2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC
  • DIP: 56211
  • STRING: ENSP00000383392
• Other Databases: GeneCards:  NCAM2  Malacards:  NCAM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043005	neuron projection	IBA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007158	neuron cell-cell adhesion	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0016021	integral component of membrane	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0030424	axon	IEA	cellular component
GO:0007608	sensory perception of smell	IEA	biological process
GO:0007413	axonal fasciculation	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04514	Cell adhesion molecules
hsa05020	Prion diseases

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq