• Gene id: 4666

Gene Summary

• Gene Symbol: NACA   Gene   UCSC   Ensembl
• Aliases: HSD48, NAC-alpha, NACA1, skNAC
• Gene name: nascent polypeptide associated complex subunit alpha
• Alternate names: nascent polypeptide-associated complex subunit alpha, alpha-NAC, muscle-specific form, nascent-polypeptide-associated complex alpha polypeptide,
• Gene location: 12q13.3 (56725298: 56712426)     Exons: 11     NC_000012.12
• Gene summary(Entrez): This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocki
• OMIM: 601234

Protein Summary

• Protein general information: Q13765  
  • Name: Nascent polypeptide associated complex subunit alpha (NAC alpha) (Alpha NAC) (allergen Hom s 2)
  • Length: 215  
  • Mass: 23384
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKK
  ARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAV
  SNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM

• Structural information:
  • Protein Domains: (70..13-)
    (/note="NAC-A/B-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00507-)
    (176..21-)
    (/note="UBA"-)
  • Interpro: IPR016641  IPR038187  IPR002715  
  • Prosite: PS51151
  • PDB: 3LKX 3MCB 3MCE
  • PDBsum: 3LKX 3MCB 3MCE
  • DIP: 43878
• Other Databases: GeneCards:  NACA  Malacards:  NACA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005854	nascent polypeptide-associated complex	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005854	nascent polypeptide-associated complex	TAS	cellular component
GO:0006412	translation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0003713	transcription coactivator activity	NAS	molecular function
GO:0003231	cardiac ventricle development	ISS	biological process
GO:0010664	negative regulation of striated muscle cell apoptotic process	ISS	biological process
GO:0043403	skeletal muscle tissue regeneration	ISS	biological process
GO:0048633	positive regulation of skeletal muscle tissue growth	ISS	biological process
GO:0048742	regulation of skeletal muscle fiber development	ISS	biological process
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	ISS	biological process
GO:0005634	nucleus	NAS	cellular component
GO:0061384	heart trabecula morphogenesis	ISS	biological process
GO:1901227	negative regulation of transcription from RNA polymerase II promoter involved in heart development	ISS	biological process
GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development	ISS	biological process
GO:0042060	wound healing	ISS	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04928	Parathyroid hormone synthesis, secretion and action

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881