• Gene id: 4499

Gene Summary

• Gene Symbol: MT1M   Gene   UCSC   Ensembl
• Aliases: MT-1M, MT-IM, MT1, MT1K
• Gene name: metallothionein 1M
• Alternate names: metallothionein-1M, metallothionein 1K, metallothionein 1Y,
• Gene location: 16q13 (56632658: 56633980)     Exons: 3     NC_000016.10
• Gene summary(Entrez): This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [
• OMIM: 156357

Protein Summary

• Protein general information: Q8N339  
  • Name: Metallothionein 1M (MT 1M) (Metallothionein IM) (MT IM)
  • Length: 61  
  • Mass: 6110
• Sequence:

  MDPNCSCTTGVSCACTGSCTCKECKCTSCKKSCCSCCPVGCAKCAHGCVCKGTLENCSCCA

• Structural information:
  • Interpro: IPR003019  IPR017854  IPR023587  IPR000006  IPR018064  
  • Prosite: PS00203
  • STRING: ENSP00000369146
• Other Databases: GeneCards:  MT1M  Malacards:  MT1M

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0071276	cellular response to cadmium ion	IBA	biological process
GO:0071280	cellular response to copper ion	IBA	biological process
GO:0071294	cellular response to zinc ion	IBA	biological process
GO:0006882	cellular zinc ion homeostasis	IBA	biological process
GO:0010273	detoxification of copper ion	IBA	biological process
GO:0046872	metal ion binding	IBA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010273	detoxification of copper ion	IEA	biological process
GO:0009617	response to bacterium	IEA	biological process
GO:0006882	cellular zinc ion homeostasis	IEA	biological process
GO:0007263	nitric oxide mediated signal transduction	IEA	biological process
GO:0008270	zinc ion binding	ISS	molecular function
GO:0071294	cellular response to zinc ion	ISS	biological process
GO:0045926	negative regulation of growth	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04978	Mineral absorption

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)