• Gene id: 4489

Gene Summary

• Gene Symbol: MT1A   Gene   UCSC   Ensembl
• Aliases: MT-1A, MT-IA, MT1, MT1S, MTC
• Gene name: metallothionein 1A
• Alternate names: metallothionein-1A, metallothionein 1A (functional), metallothionein 1S, metallothionein-IA,
• Gene location: 16q13 (56638665: 56640086)     Exons: 3     NC_000016.10
• Gene summary(Entrez): This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate meta
• OMIM: 156350

Protein Summary

• Protein general information: P04731  
  • Name: Metallothionein 1A (MT 1A) (Metallothionein IA) (MT IA)
  • Length: 61  
  • Mass: 6120
• Sequence:

  MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA

• Structural information:
  • Interpro: IPR003019  IPR017854  IPR023587  IPR000006  IPR018064  
  • Prosite: PS00203
  • STRING: ENSP00000478425
• Other Databases: GeneCards:  MT1A  Malacards:  MT1A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0071276	cellular response to cadmium ion	IBA	biological process
GO:0071280	cellular response to copper ion	IBA	biological process
GO:0071294	cellular response to zinc ion	IBA	biological process
GO:0006882	cellular zinc ion homeostasis	IBA	biological process
GO:0010273	detoxification of copper ion	IBA	biological process
GO:0046872	metal ion binding	IBA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0010038	response to metal ion	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0008270	zinc ion binding	ISS	molecular function
GO:0071294	cellular response to zinc ion	IEP	biological process
GO:0071276	cellular response to cadmium ion	IEP	biological process
GO:0045926	negative regulation of growth	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04978	Mineral absorption

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)