• Gene id: 4360

Gene Summary

• Gene Symbol: MRC1   Gene   UCSC   Ensembl
• Aliases: CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
• Gene name: mannose receptor C-type 1
• Alternate names: macrophage mannose receptor 1, C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1,
• Gene location: 10p12.33 (17809347: 17911163)     Exons: 30     NC_000010.11
• Gene summary(Entrez): The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a
• OMIM: 153618

Protein Summary

• Protein general information: P22897  
  • Name: Macrophage mannose receptor 1 (MMR) (C type lectin domain family 13 member D) (C type lectin domain family 13 member D like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1 like protein 1) (CD antigen CD206)
  • Length: 1456  
  • Mass: 166012
• Sequence:

  MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCL
  GVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCS
  RGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPL
  TSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
  LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYK
  IHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLR
  GEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTF
  AEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
  VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFE
  SRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNV
  EYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNAR
  AFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
  TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARK
  ACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDA
  DCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKL
  HNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
  TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIES
  AAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSY
  KGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFE
  NTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI

• Structural information:
  • Protein Domains: (22..14-)
    lectin (/note="Ricin-B-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00174-)
    (163..21-)
    (/note="Fibronectin-type-II)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00479-)
    (225..34-)
    1 (/note="C-type-lectin)
    (/evidence="ECO:0-)
  • Interpro: IPR001304  IPR016186  IPR018378  IPR016187  IPR000562   IPR036943  IPR013806  IPR035992  IPR000772  
  • Prosite: PS00615 PS50041 PS00023 PS51092 PS50231
  • CDD: cd00062 cd00161
  • PDB: 1EGG 1EGI 5XTS 5XTW 6INN 6INO 6INU 6INV 6IOE
  • PDBsum: 1EGG 1EGI 5XTS 5XTW 6INN 6INO 6INU 6INV 6IOE
  • DIP: 101
  • STRING: ENSP00000455897
• Other Databases: GeneCards:  MRC1  Malacards:  MRC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0038023	signaling receptor activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0006898	receptor-mediated endocytosis	IBA	biological process
GO:0038024	cargo receptor activity	IDA	molecular function
GO:0010008	endosome membrane	IDA	cellular component
GO:0006898	receptor-mediated endocytosis	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0001618	virus receptor activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005537	mannose binding	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0071346	cellular response to interferon-gamma	IEA	biological process
GO:0071222	cellular response to lipopolysaccharide	IEA	biological process
GO:0071353	cellular response to interleukin-4	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0005537	mannose binding	IEA	molecular function
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0010008	endosome membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0046718	viral entry into host cell	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05152	Tuberculosis
hsa04145	Phagosome

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)