Gene id |
4319 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
MMP10 Gene UCSC Ensembl |
Aliases |
SL-2, STMY2 |
Gene name |
matrix metallopeptidase 10 |
Alternate names |
stromelysin-2, MMP-10, matrix metalloprotease 10, matrix metalloproteinase 10 (stromelysin 2), matrix metalloproteinase-10, transin 2, |
Gene location |
11q22.2 (102780627: 102770501) Exons: 10 NC_000011.10
|
Gene summary(Entrez) |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
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Protein Summary
|
Protein general information
| P09238
Name: Stromelysin 2 (SL 2) (EC 3.4.24.22) (Matrix metalloproteinase 10) (MMP 10) (Transin 2)
Length: 476 Mass: 54151
|
Sequence |
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVT GKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSR LYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGL FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGI HTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFS GSSQFEFDPNARMVTHILKSNSWLHC
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Structural information |
|
Other Databases |
GeneCards: MMP10 Malacards: MMP10 |
|
GO accession | Term name | Evidence code | Go category |
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GO:0030574 |
collagen catabolic proces s
|
IBA |
biological process |
GO:0030198 |
extracellular matrix orga nization
|
IBA |
biological process |
GO:0004222 |
metalloendopeptidase acti vity
|
IBA |
molecular function |
GO:0008270 |
zinc ion binding
|
IEA |
molecular function |
GO:0031012 |
extracellular matrix
|
IEA |
cellular component |
GO:0006508 |
proteolysis
|
IEA |
biological process |
GO:0008237 |
metallopeptidase activity
|
IEA |
molecular function |
GO:0004222 |
metalloendopeptidase acti vity
|
IEA |
molecular function |
GO:0046872 |
metal ion binding
|
IEA |
molecular function |
GO:0006508 |
proteolysis
|
IEA |
biological process |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0008233 |
peptidase activity
|
IEA |
molecular function |
GO:0016787 |
hydrolase activity
|
IEA |
molecular function |
GO:0008237 |
metallopeptidase activity
|
IEA |
molecular function |
GO:0030574 |
collagen catabolic proces s
|
IEA |
biological process |
GO:0008270 |
zinc ion binding
|
TAS |
molecular function |
GO:0004222 |
metalloendopeptidase acti vity
|
TAS |
molecular function |
GO:0031012 |
extracellular matrix
|
TAS |
cellular component |
GO:0005615 |
extracellular space
|
TAS |
cellular component |
GO:0006508 |
proteolysis
|
TAS |
biological process |
GO:0004222 |
metalloendopeptidase acti vity
|
TAS |
molecular function |
GO:0004222 |
metalloendopeptidase acti vity
|
TAS |
molecular function |
GO:0030574 |
collagen catabolic proces s
|
TAS |
biological process |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0005576 |
extracellular region
|
TAS |
cellular component |
GO:0022617 |
extracellular matrix disa ssembly
|
TAS |
biological process |
|
|
Associated diseases |
References |
Adrenoleukodystrophy | PMID:23185624 |
diabetes mellitus | PMID:11159210 |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
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