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Gene id 4319
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol MMP10   Gene   UCSC   Ensembl
Aliases SL-2, STMY2
Gene name matrix metallopeptidase 10
Alternate names stromelysin-2, MMP-10, matrix metalloprotease 10, matrix metalloproteinase 10 (stromelysin 2), matrix metalloproteinase-10, transin 2,
Gene location 11q22.2 (102780627: 102770501)     Exons: 10     NC_000011.10
Gene summary(Entrez) This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t

Protein Summary

Protein general information P09238  

Name: Stromelysin 2 (SL 2) (EC 3.4.24.22) (Matrix metalloproteinase 10) (MMP 10) (Transin 2)

Length: 476  Mass: 54151

Sequence MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVT
GKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSR
LYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGL
FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGI
HTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFS
GSSQFEFDPNARMVTHILKSNSWLHC
Structural information
Interpro:  IPR000585  IPR036375  IPR018487  IPR018486  IPR033739  
IPR024079  IPR001818  IPR021190  IPR021158  IPR006026  IPR002477  IPR036365  
Prosite:   PS00546 PS00024 PS51642 PS00142
CDD:   cd00094 cd04278

PDB:  
1Q3A 3V96 4ILW
PDBsum:   1Q3A 3V96 4ILW
STRING:   ENSP00000279441
Other Databases GeneCards:  MMP10  Malacards:  MMP10

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0030574 collagen catabolic proces
s
IBA biological process
GO:0030198 extracellular matrix orga
nization
IBA biological process
GO:0004222 metalloendopeptidase acti
vity
IBA molecular function
GO:0008270 zinc ion binding
IEA molecular function
GO:0031012 extracellular matrix
IEA cellular component
GO:0006508 proteolysis
IEA biological process
GO:0008237 metallopeptidase activity
IEA molecular function
GO:0004222 metalloendopeptidase acti
vity
IEA molecular function
GO:0046872 metal ion binding
IEA molecular function
GO:0006508 proteolysis
IEA biological process
GO:0005576 extracellular region
IEA cellular component
GO:0008233 peptidase activity
IEA molecular function
GO:0016787 hydrolase activity
IEA molecular function
GO:0008237 metallopeptidase activity
IEA molecular function
GO:0030574 collagen catabolic proces
s
IEA biological process
GO:0008270 zinc ion binding
TAS molecular function
GO:0004222 metalloendopeptidase acti
vity
TAS molecular function
GO:0031012 extracellular matrix
TAS cellular component
GO:0005615 extracellular space
TAS cellular component
GO:0006508 proteolysis
TAS biological process
GO:0004222 metalloendopeptidase acti
vity
TAS molecular function
GO:0004222 metalloendopeptidase acti
vity
TAS molecular function
GO:0030574 collagen catabolic proces
s
TAS biological process
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0022617 extracellular matrix disa
ssembly
TAS biological process
Associated diseases References
Adrenoleukodystrophy PMID:23185624
diabetes mellitus PMID:11159210
Aberrant CpGs in Low Motility Sperm MIK: 21674046

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract