• Gene id: 4296

Gene Summary

• Gene Symbol: MAP3K11   Gene   UCSC   Ensembl
• Aliases: MEKK11, MLK-3, MLK3, PTK1, SPRK
• Gene name: mitogen-activated protein kinase kinase kinase 11
• Alternate names: mitogen-activated protein kinase kinase kinase 11, SH3 domain-containing proline-rich kinase, mixed lineage kinase 3, protein-tyrosine kinase PTK1, src-homology 3 domain-containing proline-rich kinase,
• Gene location: 11q13.1 (65614220: 65597754)     Exons: 11     NC_000074.6
• Gene summary(Entrez): The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK sig
• OMIM: 600050

KEGG pathways

Pathway id	Pathway name
hsa04932	Non-alcoholic fatty liver disease
hsa04010	MAPK signaling pathway
hsa04932	Non-alcoholic fatty liver disease

Diseases

Associated diseases	References
Plays a role in acrosome development	MIK: 17377140
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Plays a role in acrosome development	MIK: 17377140

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17377140	Plays a role in acrosome development				Male infertility
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881