• Gene id: 4293

Gene Summary

• Gene Symbol: MAP3K9   Gene   UCSC   Ensembl
• Aliases: MEKK9, MLK1, PRKE1
• Gene name: mitogen-activated protein kinase kinase kinase 9
• Alternate names: mitogen-activated protein kinase kinase kinase 9, mixed lineage kinase 1 (tyr and ser/thr specificity),
• Gene location: 14q24.2 (70809512: 70722525)     Exons: 16     NC_000014.9
• OMIM: 614061

Protein Summary

• Protein general information: P80192  
  • Name: Mitogen activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)
  • Length: 1104  
  • Mass: 121895
  • Tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. {ECO
• Sequence:

  MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRL
  GDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEII
  GIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG
  GPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
  WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP
  EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEE
  LTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQ
  HKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
  PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEM
  EDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCE
  VALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLL
  GDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH
  VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRW
  NTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLP
  ALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS

• Structural information:
  • Protein Domains: (52..11-)
    (/note="SH3-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (144..41-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR035779  IPR016231  IPR000719  IPR017441   IPR001245  IPR008271  IPR036028  IPR001452  
  • Prosite: PS00107 PS50011 PS00108 PS50002
  • CDD: cd12059
  • PDB: 3DTC 4UY9
  • PDBsum: 3DTC 4UY9
  • STRING: ENSP00000451263
• Other Databases: GeneCards:  MAP3K9  Malacards:  MAP3K9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000186	activation of MAPKK activity	IEA	biological process
GO:0000186	activation of MAPKK activity	IEA	biological process
GO:0007256	activation of JNKK activity	IEA	biological process
GO:0007256	activation of JNKK activity	IEA	biological process
GO:0046777	protein autophosphorylation	IDA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0004708	MAP kinase kinase activity	NAS	molecular function
GO:0004706	JUN kinase kinase kinase activity	ISS	molecular function
GO:0042803	protein homodimerization activity	ISS	molecular function
GO:0007257	activation of JUN kinase activity	ISS	biological process
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0007257	activation of JUN kinase activity	IBA	biological process
GO:0004706	JUN kinase kinase kinase activity	IBA	molecular function
GO:0004672	protein kinase activity	IBA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0008219	cell death	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq