• Gene id: 4282

Gene Summary

• Gene Symbol: MIF   Gene   UCSC   Ensembl
• Aliases: GIF, GLIF, MMIF
• Gene name: macrophage migration inhibitory factor
• Alternate names: macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, macrophage migration inhibitory factor (glycosylation-inhibiting factor), phenylpyruvate tautomerase,
• Gene location: 22q11.23 (23894377: 23895221)     Exons: 3     NC_000022.11
• Gene summary(Entrez): This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This l
• OMIM: 153620

Protein Summary

• Protein general information: P14174  
  • Name: Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation inhibiting factor) (GIF) (L dopachrome isomerase) (L dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
  • Length: 115  
  • Mass: 12,476
• Sequence:

  MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRS
  YSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

• Structural information:
  • Interpro: IPR001398  IPR019829  IPR014347  
  • Prosite: PS01158
  • PDB: 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ
  • PDBsum: 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ
  • DIP: 31137
  • STRING: ENSP00000215754
• Other Databases: GeneCards:  MIF  Malacards:  MIF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001516	prostaglandin biosynthetic process	IDA	biological process
GO:0002906	negative regulation of mature B cell apoptotic process	IEA	biological process
GO:0004167	dopachrome isomerase activity	IDA	molecular function
GO:0005102	receptor binding	IPI	molecular function
GO:0005125	cytokine activity	IDA	molecular function
GO:0005126	cytokine receptor binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IDA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	IDA	biological process
GO:0007569	cell aging	IEA	biological process
GO:0008283	cell proliferation	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0010629	negative regulation of gene expression	IDA	biological process
GO:0010739	positive regulation of protein kinase A signaling	IDA	biological process
GO:0019752	carboxylic acid metabolic process	IDA	biological process
GO:0030330	DNA damage response, signal transduction by p53 class mediator	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	IDA	biological process
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IEA	biological process
GO:0031982	vesicle	IDA	cellular component
GO:0032269	negative regulation of cellular protein metabolic process	IEA	biological process
GO:0033033	negative regulation of myeloid cell apoptotic process	IEA	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	biological process
GO:0042056	chemoattractant activity	IDA	molecular function
GO:0042327	positive regulation of phosphorylation	IDA	biological process
GO:0043030	regulation of macrophage activation	NAS	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043406	positive regulation of MAP kinase activity	IEA	biological process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IDA	biological process
GO:0050178	phenylpyruvate tautomerase activity	IDA	molecular function
GO:0050715	positive regulation of cytokine secretion	IDA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0050918	positive chemotaxis	IEA	biological process
GO:0061078	positive regulation of prostaglandin secretion involved in immune response	IEA	biological process
GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070207	protein homotrimerization	IPI	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0071157	negative regulation of cell cycle arrest	IDA	biological process
GO:0090238	positive regulation of arachidonic acid secretion	IEA	biological process
GO:0090344	negative regulation of cell aging	IDA	biological process
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA	biological process
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA	biological process
GO:0001516	prostaglandin biosynthetic process	IDA	biological process
GO:0001934	positive regulation of protein phosphorylation	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0002906	negative regulation of mature B cell apoptotic process	IEA	biological process
GO:0004167	dopachrome isomerase activity	IEA	molecular function
GO:0004167	dopachrome isomerase activity	IDA	molecular function
GO:0005102	receptor binding	IPI	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005125	cytokine activity	IDA	molecular function
GO:0005126	cytokine receptor binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IDA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	IDA	biological process
GO:0007569	cell aging	IEA	biological process
GO:0008283	cell proliferation	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0010629	negative regulation of gene expression	IDA	biological process
GO:0010739	positive regulation of protein kinase A signaling	IDA	biological process
GO:0016853	isomerase activity	IEA	molecular function
GO:0019752	carboxylic acid metabolic process	IDA	biological process
GO:0030330	DNA damage response, signal transduction by p53 class mediator	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	IDA	biological process
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IEA	biological process
GO:0031982	vesicle	IDA	cellular component
GO:0032269	negative regulation of cellular protein metabolic process	IEA	biological process
GO:0033033	negative regulation of myeloid cell apoptotic process	IEA	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	biological process
GO:0042056	chemoattractant activity	IDA	molecular function
GO:0042127	regulation of cell proliferation	IEA	biological process
GO:0042327	positive regulation of phosphorylation	IDA	biological process
GO:0043030	regulation of macrophage activation	NAS	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043406	positive regulation of MAP kinase activity	IEA	biological process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA	biological process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IEA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IDA	biological process
GO:0050178	phenylpyruvate tautomerase activity	IEA	molecular function
GO:0050178	phenylpyruvate tautomerase activity	IEA	molecular function
GO:0050178	phenylpyruvate tautomerase activity	IDA	molecular function
GO:0050715	positive regulation of cytokine secretion	IDA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0050918	positive chemotaxis	IEA	biological process
GO:0061078	positive regulation of prostaglandin secretion involved in immune response	IEA	biological process
GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070207	protein homotrimerization	IPI	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0071157	negative regulation of cell cycle arrest	IDA	biological process
GO:0090238	positive regulation of arachidonic acid secretion	IEA	biological process
GO:0090344	negative regulation of cell aging	IDA	biological process
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA	biological process
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA	biological process
GO:0001516	prostaglandin biosynthetic process	IDA	biological process
GO:0004167	dopachrome isomerase activity	IDA	molecular function
GO:0005102	receptor binding	IPI	molecular function
GO:0005125	cytokine activity	IDA	molecular function
GO:0005126	cytokine receptor binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IDA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0007166	cell surface receptor signaling pathway	IDA	biological process
GO:0008283	cell proliferation	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0010629	negative regulation of gene expression	IDA	biological process
GO:0010739	positive regulation of protein kinase A signaling	IDA	biological process
GO:0019752	carboxylic acid metabolic process	IDA	biological process
GO:0030890	positive regulation of B cell proliferation	IDA	biological process
GO:0031982	vesicle	IDA	cellular component
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	biological process
GO:0042056	chemoattractant activity	IDA	molecular function
GO:0042327	positive regulation of phosphorylation	IDA	biological process
GO:0043030	regulation of macrophage activation	NAS	biological process
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	biological process
GO:0048146	positive regulation of fibroblast proliferation	IDA	biological process
GO:0050178	phenylpyruvate tautomerase activity	IDA	molecular function
GO:0050715	positive regulation of cytokine secretion	IDA	biological process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	biological process
GO:0050900	leukocyte migration	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070207	protein homotrimerization	IPI	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0071157	negative regulation of cell cycle arrest	IDA	biological process
GO:0090344	negative regulation of cell aging	IDA	biological process
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways

Diseases

Associated diseases	References
Cancer (lung)	GAD: 19773451
Cancer (prostate)	GAD: 19475570
Cancer	GAD: 19773451
Cancer (meningeal)	GAD: 20406964
Cardiovascular disease	GAD: 17029206
Atherosclerosis	GAD: 18242614
Cystic fibrosis	GAD: 16179637
Cystic fibrosis	GAD: 16179637
Gastric mucosa	GAD: 19724898
Chronic ulcerative colitis	GAD: 20621719
Anemia	GAD: 19591577
Sarcoidosis	GAD: 12180727
Sarcoidosis	GAD: 17005573
Sarcoidosis	GAD: 17005573
Anemia	GAD: 19591577
Atopy	GAD: 14962818
Arthritis	GAD: 11508429
Asthma	GAD: 14962818
Ulcerative colitis	GAD: 15065001
Alopecia areata	GAD: 15815686
Arthritis	GAD: 16220288
Arthritis	GAD: 12355488
Rheumatoid arthritis	GAD: 12070782
Asthma	GAD: 19317738
Juvenile arthritis	GAD: 12746913
Juvenile arthritis	GAD: 12195624
Pancreatitis	GAD: 17495357
Ulcerative colitis	GAD: 15065001
Rheumatoid arthritis	GAD: 15018649
Rheumatoid arthritis	GAD: 16200611
Juvenile arthritis	GAD: 12746913
Rheumatoid arthritis	GAD: 12070782
Psoriasis	GAD: 15304087
Psoriasis	GAD: 19157791
Inflammatory response in coronary bypass	GAD: 16527487
Psoriasis	GAD: 15304087
Multiple sclerosis	GAD: 20233515
Systemic lupus erythematosus (SLE)	GAD: 16724072
Systemic lupus erythematosus (SLE)	GAD: 16724072
Crohn's disease	GAD: 17172590
Cutaneous vasculitis	GAD: 17181929
Crohn's disease	GAD: 17206642
Atopy	GAD: 14962818
Arthritis	GAD: 11508429
Asthma	GAD: 14962818
Crohn's disease	GAD: 17172590
Cutaneous vasculitis	GAD: 17181929
Biliary atresia	GAD: 16385258
Diabetes	GAD: 18853133
Obesity	GAD: 16247506
Obesity	GAD: 16247506
Diabetes	GAD: 18853133
Biliary atresia	GAD: 16385258
Bone diseases	GAD: 20471506
Juvenile idiopathic arthritis	GAD: 12355488
Juvenile idiopathic arthritis	GAD: 12355488
Juvenile idiopathic arthritis	KEGG: H01672
Stroke	GAD: 15308783
Stroke	GAD: 15308783
Giant cell arteritis	GAD: 15630728
Alzheimer's disease	GAD: 15286457
Amyotrophic lateral sclerosis (ALS)	GAD: 18608101
Amyotrophic lateral sclerosis (ALS)	GAD: 18608101
Alzheimer's disease	GAD: 15286457
Polyarthritis	GAD: 14551601
Kidney diseases	GAD: 16133063
Endometriosis	INFBASE: 17706208
Poor ovarian response (POR)	INFBASE: 25083184
Endometriosis	INFBASE: 19230876
Endometriosis-associated infertility	INFBASE: 20492386
Endometriosis	INFBASE: 16616746
Endometriosis	INFBASE: 25439837
Endometriosis	INFBASE: 19299454
Endometriosis	INFBASE: 20829186
Ectopic endometriosis	INFBASE: 18710704
Endometriosis	INFBASE: 17997749
Endometriosis	INFBASE: 11836337
Endometriosis	INFBASE: 12009356
Fertilizing defects	INFBASE: 7039539
Female infertility	INFBASE: 1090165
Recurrent pregnancy loss (RPL)	INFBASE: 26368793
Recurrent pregnancy loss (RPL)	INFBASE: 26368793
Polycystic ovary syndrome (PCOS)	INFBASE: 21623990
Male pseudohermaphroditism	MIK: 3426164
Testicular descent	MIK: 9340616
Testicular descent	MIK: 9340616
Sperm maturation and motility	MIK: 17592555
Sperm maturation and motility	MIK: 17592555
Male pseudohermaphroditism	MIK: 3426164
Chorioamnionitis	GAD: 20452482
Fertilizing defects	MIK: 7039539
Female infertility	INFBASE: 17658526
Tooth loss	GAD: 16538639
Atrophy	GAD: 17786285
Nephrotic syndrome	GAD: 18228042
Chronic renal failure	GAD: 20303284
Kidney diseases	GAD: 16133063
Fertility disorders	MIK: 7039539
Male pseudohermaphroditism	MIK: 3426164
Sperm maturation and motility	MIK: 17592555
Male infertility	MIK: 17592555
Teratozoospermia	MIK: 17327269
Testicular descent	MIK: 9340616

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17592555	Sperm maturation and motility, Male infertility				Male infertility
3426164	Male pseudohermaphroditism			1 Male pseudohermaphroditism	Male infertility
9340616	Testicular descent			1 persistent mullerian duct syndrome (PMDS) with transverse testicular ectopia and inguinal hernia	Male infertility
7039539	Fertility disorders			29 infertile men, 16 of whom were also examined towards normal seminal fluid.	Male infertility	MIF
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)