• Gene id: 4277

Gene Summary

• Gene Symbol: MICB   Gene   UCSC   Ensembl
• Aliases: PERB11.2
• Gene name: MHC class I polypeptide-related sequence B
• Alternate names: MHC class I polypeptide-related sequence B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog,
• Gene location: 6p21.33 (31494880: 31511123)     Exons: 7     NC_000006.12
• Gene summary(Entrez): This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the recepto
• OMIM: 602436

Protein Summary

• Protein general information: Q29980  
  • Name: MHC class I polypeptide related sequence B (MIC B)
  • Length: 383  
  • Mass: 42646
  • Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumo
• Sequence:

  MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDESVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAED
  VLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQES
  TVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTC
  RASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKV
  LVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATG
  STGSTEGA

• Structural information:
  • Protein Domains: (207..29-)
    (/note="Ig-like-C1-type)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR007110  IPR036179  IPR013783  IPR003597  IPR011161   IPR037055  IPR011162  
  • Prosite: PS50835
  • PDB: 1JE6 2WY3
  • PDBsum: 1JE6 2WY3
  • STRING: ENSP00000252229
• Other Databases: GeneCards:  MICB  Malacards:  MICB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0019835	cytolysis	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0016032	viral process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0002250	adaptive immune response	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0050776	regulation of immune response	TAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0032526	response to retinoic acid	IDA	biological process
GO:0006979	response to oxidative stress	IDA	biological process
GO:0050689	negative regulation of defense response to virus by host	IDA	biological process
GO:0046703	natural killer cell lectin-like receptor binding	IDA	molecular function
GO:0009408	response to heat	IDA	biological process
GO:0002429	immune response-activating cell surface receptor signaling pathway	IDA	biological process
GO:0050689	negative regulation of defense response to virus by host	IDA	biological process
GO:0046629	gamma-delta T cell activation	IDA	biological process
GO:0009986	cell surface	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa04650	Natural killer cell mediated cytotoxicity

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)