• Gene id: 4267

Gene Summary

• Gene Symbol: CD99   Gene   UCSC   Ensembl
• Aliases: HBA71, MIC2, MIC2X, MIC2Y, MSK5X
• Gene name: CD99 molecule (Xg blood group)
• Alternate names: CD99 antigen, E2 antigen, MIC2 (monoclonal antibody 12E7), T-cell surface glycoprotein E2, antigen identified by monoclonal 12E7, Y homolog, antigen identified by monoclonal antibodies 12E7, F21 and O13, cell surface antigen 12E7, cell surface antigen HBA,
• Gene location: Xp22.33 and Yp11.2 (2691132: 2741308)     Exons: 11     NC_000023.11
• Gene summary(Entrez): The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may
• OMIM: 3.1347E+11

Protein Summary

• Protein general information: P14209  
  • Name: CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T cell surface glycoprotein E2) (CD antigen CD99)
  • Length: 185  
  • Mass: 18,848
• Sequence:

  MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKP
  MPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQK
  KKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK

• Structural information:
  • Interpro: IPR022078  
  • STRING: ENSP00000370588
• Other Databases: GeneCards:  CD99  Malacards:  CD99

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0005737	cytoplasm	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04514	Cell adhesion molecules
hsa04670	Leukocyte transendothelial migration

Diseases

Associated diseases	References
Arthritis	GAD: 19723899
Male factor infertility	MIK: 14678384
Cryptorchidism	MIK: 14678384
Cryptorchid testes	MIK: 14678384
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
14678384	Cryptorchid testes			189 cases of undescended testicles	Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray