• Gene id: 4256

Gene Summary

• Gene Symbol: MGP   Gene   UCSC   Ensembl
• Aliases: GIG36, MGLAP, NTI
• Gene name: matrix Gla protein
• Alternate names: matrix Gla protein, cell growth-inhibiting gene 36 protein,
• Gene location: 12p12.3 (14885853: 14880863)     Exons: 5     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification.
• OMIM: 610658

Protein Summary

• Protein general information: P08493  
  • Name: Matrix Gla protein (MGP) (Cell growth inhibiting gene 36 protein)
  • Length: 103  
  • Mass: 12353
• Sequence:

  MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDD
  YRLCERYAMVYGYNAAYNRYFRKRRGTK

• Structural information:
  • Protein Domains: (51..9-)
    (/note="Gla-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00463"-)
  • Interpro: IPR035972  IPR000294  IPR027118  IPR002384  
  • Prosite: PS00011 PS50998
• Other Databases: GeneCards:  MGP  Malacards:  MGP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031012	extracellular matrix	IBA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0031012	extracellular matrix	IEA	cellular component
GO:0062023	collagen-containing extracellular matrix	IEA	cellular component
GO:0030500	regulation of bone mineralization	IEA	biological process
GO:0001503	ossification	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0051216	cartilage development	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0005201	extracellular matrix structural constituent	TAS	molecular function
GO:0008147	structural constituent of bone	TAS	molecular function
GO:0001502	cartilage condensation	TAS	biological process
GO:0031012	extracellular matrix	TAS	cellular component
GO:0001503	ossification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0062023	collagen-containing extracellular matrix	HDA	colocalizes with
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Keutel syndrome	KEGG:H00500
Keutel syndrome	KEGG:H00500
Prostate cancer	PMID:1399132
Calcinosis	PMID:15045141
Arteriosclerosis	PMID:8200973
Germinoma	PMID:1399132
renal cell carcinoma	PMID:1399132
Myocardial infarction	PMID:11073842
cervix uteri carcinoma in situ	PMID:17960611
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881