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Gene id 4233
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol MET   Gene   UCSC   Ensembl
Aliases AUTS9, DFNB97, HGFR, RCCP2, c-Met
Gene name MET proto-oncogene, receptor tyrosine kinase
Alternate names hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met,
Gene location 7q31.2 (116672195: 116798385)     Exons: 24     NC_000007.14
Gene summary(Entrez) This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form
OMIM 164860

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa00020Citrate cycle
hsa00051Fructose and mannose metabolism
hsa00500Starch and sucrose metabolism
hsa00140Steroid hormone biosynthesis
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
hsa03050Proteasome
hsa03018RNA degradation
hsa03410Base excision repair
hsa03430Mismatch repair
hsa02010ABC transporters
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04014Ras signaling pathway
hsa04012ErbB signaling pathway
hsa04330Notch signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04360Axon guidance
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05230Central carbon metabolism in cancer
hsa05225Hepatocellular carcinoma
hsa05226Gastric cancer
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05100Bacterial invasion of epithelial cells
hsa05144Malaria
hsa01521EGFR tyrosine kinase inhibitor resistance
Associated diseases References
Endometriosis INFBASE: 9022601
Spermatogenic defects MIK: 10520577

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
10520577 Role in sp
erm functi
on


Male infertility
Show abstract