• Gene id: 4200

Gene Summary

• Gene Symbol: ME2   Gene   UCSC   Ensembl
• Aliases: ODS1
• Gene name: malic enzyme 2
• Alternate names: NAD-dependent malic enzyme, mitochondrial, NAD-ME, malate dehydrogenase (oxaloacetate-decarboxylating), malic enzyme 2, NAD(+)-dependent, mitochondrial, pyruvic-malic carboxylase,
• Gene location: 18q21.2 (50878701: 50954256)     Exons: 16     NC_000018.10
• Gene summary(Entrez): This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been s
• OMIM: 602845

Protein Summary

• Protein general information: P23368  
  • Name: NAD dependent malic enzyme, mitochondrial (NAD ME) (EC 1.1.1.38) (Malic enzyme 2)
  • Length: 584  
  • Mass: 65444
• Sequence:

  MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKM
  TSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNW
  PENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKR
  DRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK
  PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPD
  TFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFG
  PVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSIN
  IAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

• Structural information:
  • Interpro: IPR015884  IPR012301  IPR037062  IPR012302  IPR001891   IPR036291  
  • Prosite: PS00331
  • PDB: 1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6
  • PDBsum: 1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6
  • STRING: ENSP00000321070
• Other Databases: GeneCards:  ME2  Malacards:  ME2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004470	malic enzyme activity	IMP	molecular function
GO:1902031	regulation of NADP metabolic process	IMP	biological process
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	IBA	molecular function
GO:0004470	malic enzyme activity	IBA	molecular function
GO:0006108	malate metabolic process	IBA	biological process
GO:0006090	pyruvate metabolic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0004470	malic enzyme activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IEA	molecular function
GO:0051287	NAD binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0008152	metabolic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	TAS	molecular function
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IEA	molecular function
GO:0008948	oxaloacetate decarboxylase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006099	tricarboxylic acid cycle	TAS	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0022900	electron transport chain	IEA	biological process
GO:0009055	electron transfer activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01200	Carbon metabolism
hsa00620	Pyruvate metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881