• Gene id: 4144

Gene Summary

• Gene Symbol: MAT2A   Gene   UCSC   Ensembl
• Aliases: MATA2, MATII, SAMS2
• Gene name: methionine adenosyltransferase 2A
• Alternate names: S-adenosylmethionine synthase isoform type-2, MAT 2, MAT-II, adoMet synthase 2, adoMet synthetase 2, methionine adenosyltransferase 2, methionine adenosyltransferase II, alpha, testicular tissue protein Li 121,
• Gene location: 2p11.2 (85539167: 85545280)     Exons: 9     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
• OMIM: 601468

Protein Summary

• Protein general information: P31153  
  • Name: S adenosylmethionine synthase isoform type 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT II)
  • Length: 395  
  • Mass: 43661
  • Tissue specificity: Detected in kidney. {ECO
• Sequence:

  MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRA
  AVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECM
  PLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEK
  VIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
  VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTA
  AYGHFGRDSFPWEVPKKLKY

• Structural information:
  • Interpro: IPR022631  IPR022630  IPR022629  IPR022628  IPR002133   IPR022636  
  • Prosite: PS00376 PS00377
  • PDB: 2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R
  • PDBsum: 2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R
  • STRING: ENSP00000303147
• Other Databases: GeneCards:  MAT2A  Malacards:  MAT2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004478	methionine adenosyltransferase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0006556	S-adenosylmethionine biosynthetic process	IBA	biological process
GO:0048269	methionine adenosyltransferase complex	IBA	cellular component
GO:0051291	protein heterooligomerization	IDA	biological process
GO:0004478	methionine adenosyltransferase activity	IDA	molecular function
GO:0048269	methionine adenosyltransferase complex	IDA	cellular component
GO:0034214	protein hexamerization	IDA	biological process
GO:0006556	S-adenosylmethionine biosynthetic process	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0004478	methionine adenosyltransferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006556	S-adenosylmethionine biosynthetic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006730	one-carbon metabolic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0004478	methionine adenosyltransferase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0032259	methylation	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004478	methionine adenosyltransferase activity	IEA	molecular function
GO:1990830	cellular response to leukemia inhibitory factor	IEA	biological process
GO:0006556	S-adenosylmethionine biosynthetic process	IEA	biological process
GO:0006556	S-adenosylmethionine biosynthetic process	IEA	biological process
GO:0004478	methionine adenosyltransferase activity	IDA	molecular function
GO:0004478	methionine adenosyltransferase activity	IDA	molecular function
GO:0048269	methionine adenosyltransferase complex	IDA	cellular component
GO:0006556	S-adenosylmethionine biosynthetic process	IDA	biological process
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01230	Biosynthesis of amino acids
hsa00270	Cysteine and methionine metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881