• Gene id: 414328

Gene Summary

• Gene Symbol: IDNK   Gene   UCSC   Ensembl
• Aliases: C9orf103, bA522I20.2, hGntK
• Gene name: IDNK gluconokinase
• Alternate names: probable gluconokinase, glucokinase-like protein, gluconate kinase, gluconokinase-like protein, idnK, gluconokinase homolog,
• Gene location: 9q21.32 (83622323: 83644129)     Exons: 5     NC_000009.12
• OMIM: 611343

Protein Summary

• Protein general information: Q5T6J7  
  • Name: Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase)
  • Length: 187  
  • Mass: 20578
• Sequence:

  MAAPGALLVMGVSGSGKSTVGALLASELGWKFYDADDYHPEENRRKMGKGIPLNDQDRIPWLCNLHDILLRDVAS
  GQRVVLACSALKKTYRDILTQGKDGVALKCEESGKEAKQAEMQLLVVHLSGSFEVISGRLLKREGHFMPPELLQS
  QFETLEPPAAPENFIQISVDKNVSEIIATIMETLKMK

• Structural information:
  • Interpro: IPR027417  IPR031322  IPR006001  
  • CDD: cd02021
  • STRING: ENSP00000365601
• Other Databases: GeneCards:  IDNK  Malacards:  IDNK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046177	D-gluconate catabolic process	IBA	biological process
GO:0046316	gluconokinase activity	IBA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0046316	gluconokinase activity	IEA	molecular function
GO:0046177	D-gluconate catabolic process	IEA	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0008150	biological_process	ND	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa00030	Pentose phosphate pathway

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray