• Gene id: 4123

Gene Summary

• Gene Symbol: MAN2C1   Gene   UCSC   Ensembl
• Aliases: MAN6A8, MANA, MANA1
• Gene name: mannosidase alpha class 2C member 1
• Alternate names: alpha-mannosidase 2C1, alpha mannosidase 6A8B, alpha-D-mannoside mannohydrolase, mannosidase, alpha 6A8, mannosidase, alpha A, cytoplasmic, testicular tissue protein Li 115,
• Gene location: 15q24.2 (75368626: 75355791)     Exons: 26     NC_000015.10

Protein Summary

• Protein general information: Q9NTJ4  
  • Name: Alpha mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha D mannoside mannohydrolase) (Mannosidase alpha class 2C member 1)
  • Length: 1040  
  • Mass: 115835
• Sequence:

  MAAAPALKHWRTTLERVEKFVSPLYFTDCNLRGRLFGASCPVAVLSSFLTPERLPYQEAVQRDFRPAQVGDSFGP
  TWWTCWFRVELTIPEAWVGQEVHLCWESDGEGLVWRDGEPVQGLTKEGEKTSYVLTDRLGERDPRSLTLYVEVAC
  NGLLGAGKGSMIAAPDPEKMFQLSRAELAVFHRDVHMLLVDLELLLGIAKGLGKDNQRSFQALYTANQMVNVCDP
  AQPETFPVAQALASRFFGQHGGESQHTIHATGHCHIDTAWLWPFKETVRKCARSWVTALQLMERNPEFIFACSQA
  QQLEWVKSRYPGLYSRIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFG
  YSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHHTFFWEGLDGSRVLVHFPPGDSYGMQGSVEEVLKTVANNRDKG
  RANHSAFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPRVQLSSPRQLFSALESDSEQLCTWVGELFLELHNGTYTT
  HAQIKKGNRECERILHDVELLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQMVAEEAMCHYEDIR
  SHGNTLLSAAAAALCAGEPGPEGLLIVNTLPWKRIEVMALPKPGGAHSLALVTVPSMGYAPVPPPTSLQPLLPQQ
  PVFVVQETDGSVTLDNGIIRVKLDPTGRLTSLVLVASGREAIAEGAVGNQFVLFDDVPLYWDAWDVMDYHLETRK
  PVLGQAGTLAVGTEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARVRSSQAT
  YEIQFGHLQRPTHYNTSWDWARFEVWAHRWMDLSEHGFGLALLNDCKYGASVRGSILSLSLLRAPKAPDATADTG
  RHEFTYALMPHKGSFQDAGVIQAAYSLNFPLLALPAPSPAPATSWSAFSVSSPAVVLETVKQAESSPQRRSLVLR
  LYEAHGSHVDCWLHLSLPVQEAILCDLLERPDPAGHLTLRDNRLKLTFSPFQVLSLLLVLQPPPH

• Structural information:
  • Interpro: IPR011013  IPR041147  IPR011330  IPR011682  IPR015341   IPR037094  IPR000602  IPR027291  IPR028995  
  • STRING: ENSP00000457788
• Other Databases: GeneCards:  MAN2C1  Malacards:  MAN2C1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009313	oligosaccharide catabolic process	IBA	biological process
GO:0004559	alpha-mannosidase activity	IBA	molecular function
GO:0004559	alpha-mannosidase activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006013	mannose metabolic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0004559	alpha-mannosidase activity	IEA	molecular function
GO:0009313	oligosaccharide catabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00511	Other glycan degradation

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881