|
Gene id |
407042 |
| Gene Summary SNPs KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
MIR34C Gene UCSC Ensembl |
|
Aliases |
MIRN34C, miRNA34C, mir-34c |
|
Gene name |
microRNA 34c |
|
Alternate names |
hsa-mir-34c, |
|
Gene location |
11q23.1 (111513438: 111513514) Exons: 1 NC_000011.10
|
|
Gene summary(Entrez) |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I
|
|
OMIM |
611375 |
SNPs |
rs4938723
Strand: Allele origin: Allele change: Mutation type: snv
NC_000011.10 g.111511840T>C
NC_000011.9 g.111382565T>C|SEQ=[T/C]|GENE=BTG4
MIR34B 407041
MIR34C 407042
LOC728196 728196
|
|
| Pathway id | Pathway name |
|---|
| hsa05206 | MicroRNAs in cancer | |
|
| Associated diseases |
References |
| Endometriosis | INFBASE: 19074548 |
| Polycystic ovary syndrome (PCOS) | INFBASE: 24390626 |
| Spermatogenesis defects | MIK: 26648257 |
| Non obstructive azoospermia | MIK: 25108464 |
| Azoospermia | MIK: 21933900 |
| Maturation arrest | MIK: 26648257 |
| Asthenozoospermia | MIK: 21933900 |
| Azoospermia | MIK: 21933900 |
| Asthenozoospermia | MIK: 21933900 |
| Cryptorchidism | MIK: 30103742 |
| Obstructive azoospermia | MIK: 30103742 |
| Male infertility | MIK: 30103742 |
| Nonobstructive azoospermia | MIK: 25108464 |
| Oligoasthenozoospermia | MIK: 23312218 |
| Oligozoospermia | MIK: 27486773 |
| Spermatogenic defects | MIK: 26648257 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 25108464 |
Male infer
tility, no
nobstructi
ve azoospe
rmia [NOA]
|
|
|
226 men present
ing at an infer
tility clinic
|
Male infertility |
miR-34b*
miR-34b
miR-34c-5p
miR-429
miR-122
|
Show abstract |
| 26648257 |
Spermatoge
nic failur
e, maturat
ion failur
e
|
|
|
|
Male infertility |
miR-449a
miR-34c-5p and miR-122
|
Show abstract |
| 21933900 |
Azoospermi
a, astheno
zoospermia
|
|
|
457 (289 infert
ile men (118 no
n obstructive a
zoospermia, 137
asthenozoosper
mia, 34 oligosp
ermia), 168 age
-matched fertil
e controls)
|
Male infertility |
miR-34c-5p
|
Show abstract |
| 27486773 |
Severe oli
gozoosperm
ia, Male i
nfertility
|
|
|
|
Male infertility |
|
Show abstract |
| 30103742 |
Cryptorchi
dism, Obst
ructive az
oospermia,
Male infe
rtility
|
|
|
6 (3 post-crypt
orchidopexy tes
ticular tissue
samples, 3 obst
ructive azoospe
rmia)
|
Male infertility |
Microarray microRNAs
|
Show abstract |
| 23312218 |
Oligoasthe
nozoosperm
ia
|
|
|
27 (9 normozoos
permia, 9 oligo
asthenozoosperm
ia, 9 asthenozo
ospermia)
|
Male infertility |
NGS
|
Show abstract |
|