• Gene id: 407041

Gene Summary

• Gene Symbol: MIR34B   Gene   UCSC   Ensembl
• Aliases: MIRN34B, miRNA34B, mir-34b
• Gene name: microRNA 34b
• Alternate names: hsa-mir-34b,
• Gene location: 11q23.1 (111512937: 111513020)     Exons: 1     NC_000011.10
• Gene summary(Entrez): microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I
• OMIM: 611374

SNPs

rs4938723

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000011.10   g.111511840T>C
NC_000011.9   g.111382565T>C|SEQ=[T/C]|GENE=BTG4
MIR34B   407041
MIR34C   407042
LOC728196   728196

KEGG pathways

Pathway id	Pathway name
hsa05206	MicroRNAs in cancer

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 25108464
Asthenozoospemia	MIK: 23312218
Cryptorchidism	MIK: 30103742
Obstructive azoospermia	MIK: 30103742
Male infertility	MIK: 30103742
Nonobstructive azoospermia	MIK: 25108464
Oligoasthenozoospermia	MIK: 23312218

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25108464	Male infertility, nonobstructive azoospermia [NOA]			226 men presenting at an infertility clinic	Male infertility	miR-34b* miR-34b miR-34c-5p miR-429 miR-122
30103742	Cryptorchidism, Obstructive azoospermia, Male infertility			6 (3 post-cryptorchidopexy testicular tissue samples, 3 obstructive azoospermia)	Male infertility	Microarray microRNAs
23312218	Asthenozoospemia			27 (9 normozoospermia, 9 oligoasthenozoospermia, 9 asthenozoospermia)	Male infertility	NGS
23312218	Oligoasthenozoospermia			27 (9 normozoospermia, 9 oligoasthenozoospermia, 9 asthenozoospermia)	Male infertility	NGS
23312218	Oligoasthenozoospermia			27 (9 normozoospermia, 9 oligoasthenozoospermia, 9 asthenozoospermia)	Male infertility	NGS
31134916	Non- obstructive azoospermia			77 (39 NOA, 38 controls)	Male infertility	Microarray