|
Gene id |
406991 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
MIR21 Gene UCSC Ensembl |
|
Aliases |
MIRN21, hsa-mir-21, miR-21, miRNA21 |
|
Gene name |
microRNA 21 |
|
Gene location |
17q23.1 (59841265: 59841336) Exons: 1 NC_000017.11
|
|
Gene summary(Entrez) |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I
|
|
OMIM |
611020 |
|
| Pathway id | Pathway name |
|---|
| hsa05206 | MicroRNAs in cancer | | hsa05205 | Proteoglycans in cancer | |
|
| Associated diseases |
References |
| Cancer | GAD: 19048628 |
| Cancer (ovarian) | GAD: 20167074 |
| Cancer (breast) | GAD: 19048628 |
| Endometriosis | INFBASE: 25910568 |
| Polycystic ovary syndrome (PCOS) | INFBASE: 26427146 |
| Oligozoospermia | MIK: 25469126 |
| Non obstructive azoospermia | MIK: 23869807 |
| Sertoli cell only syndrome | MIK: 23869807 |
| Oligoasthenozoospermia | MIK: 27424049 |
| Oligospermia | MIK: 25469126 |
| Male infertility | MIK: 25469126 |
| Plays a role in early stage of spermatogenesis | MIK: 25266152 |
| Spermatogenic failure | MIK: 22735917 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 25469126 |
Oligosperm
ic, Male i
nfertility
|
|
|
86 (43 oligospe
rmic infertile
men, 43 age mat
ched healthy co
ntrol)
|
Male infertility |
mir-21
mir-22
|
Show abstract |
| 25266152 |
Plays a ro
le in earl
y stage of
spermatog
enesis
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 23869807 |
Non obstru
ctive azoo
spermia, S
ertoli cel
l only syn
drome
|
|
|
20 (4 controls,
16 cases)
|
Male infertility |
GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 27424049 |
Oligoasthe
nozoosperm
ia
|
|
|
24 (12 normozoo
spermia, 12 Oli
goasthenozoospe
rmia)
|
Male infertility |
Microarray
|
Show abstract |
| 22735917 |
Spermatoge
nic failur
e
|
|
|
69 samples
|
Male infertility |
Microarray
|
Show abstract |
|