• Gene id: 4048

Gene Summary

• Gene Symbol: LTA4H   Gene   UCSC   Ensembl
• Gene name: leukotriene A4 hydrolase
• Alternate names: leukotriene A-4 hydrolase, LTA-4 hydrolase, testicular secretory protein Li 27,
• Gene location: 12q23.1 (96043519: 96000752)     Exons: 20     NC_000012.12
• Gene summary(Entrez): The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has b
• OMIM: 151570

Protein Summary

• Protein general information: P09960  
  • Name: Leukotriene A 4 hydrolase (LTA 4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)
  • Length: 611  
  • Mass: 69285
  • Tissue specificity: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
• Sequence:

  MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYA
  LGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDT
  PSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEK
  EQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
  SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDP
  DVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
  SPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVY
  NFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
  AMLVGKDLKVD

• Structural information:
  • Interpro: IPR042097  IPR016024  IPR012777  IPR038502  IPR034015   IPR001930  IPR015211  IPR014782  IPR027268  
  • Prosite: PS00142
  • CDD: cd09599
  • PDB: 1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR 4L2L 4MKT 4MS6 4R7L 4RSY 4RVB 5AEN 5BPP 5FWQ 5N3W 5NI2 5NI4 5NI6 5NIA 5NID 5NIE 6ENB 6ENC 6END 6O5H
  • PDBsum: 1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR 4L2L 4MKT 4MS6 4R7L 4RSY 4RVB 5AEN 5BPP 5FWQ 5N3W 5NI2 5NI4 5NI6 5NIA 5NID 5NIE 6ENB 6ENC 6END 6O5H
  • STRING: ENSP00000228740
• Other Databases: GeneCards:  LTA4H  Malacards:  LTA4H

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004301	epoxide hydrolase activity	IBA	molecular function
GO:0004463	leukotriene-A4 hydrolase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0019370	leukotriene biosynthetic process	IBA	biological process
GO:0044255	cellular lipid metabolic process	IBA	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0004177	aminopeptidase activity	IDA	molecular function
GO:0004177	aminopeptidase activity	IDA	molecular function
GO:0043171	peptide catabolic process	IDA	biological process
GO:0043171	peptide catabolic process	IDA	biological process
GO:0019370	leukotriene biosynthetic process	IDA	biological process
GO:0004463	leukotriene-A4 hydrolase activity	IDA	molecular function
GO:0004301	epoxide hydrolase activity	IDA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0019370	leukotriene biosynthetic process	IEA	biological process
GO:0008233	peptidase activity	TAS	molecular function
GO:0008270	zinc ion binding	TAS	molecular function
GO:0004463	leukotriene-A4 hydrolase activity	TAS	molecular function
GO:0019370	leukotriene biosynthetic process	TAS	biological process
GO:0004463	leukotriene-A4 hydrolase activity	IEA	molecular function
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904724	tertiary granule lumen	TAS	cellular component
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006691	leukotriene metabolic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0044267	cellular protein metabolic process	IMP	biological process
GO:0019370	leukotriene biosynthetic process	IMP	biological process
GO:0070006	metalloaminopeptidase activity	IMP	molecular function
GO:0008270	zinc ion binding	IMP	molecular function
GO:0004301	epoxide hydrolase activity	IMP	molecular function
GO:0004177	aminopeptidase activity	IDA	molecular function
GO:0019370	leukotriene biosynthetic process	IDA	biological process
GO:0004463	leukotriene-A4 hydrolase activity	IDA	molecular function
GO:0043171	peptide catabolic process	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0004301	epoxide hydrolase activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00590	Arachidonic acid metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881