• Gene id: 4036

Gene Summary

• Gene Symbol: LRP2   Gene   UCSC   Ensembl
• Aliases: DBS, GP330, LRP-2
• Gene name: LDL receptor related protein 2
• Alternate names: low-density lipoprotein receptor-related protein 2, Heymann nephritis antigen homolog, calcium sensor protein, glycoprotein 330, megalin,
• Gene location: 2q31.1 (169362596: 169127108)     Exons: 15     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycopr
• OMIM: 600073

Protein Summary

• Protein general information: P98164  
  • Name: Low density lipoprotein receptor related protein 2 (LRP 2) (Glycoprotein 330) (gp330) (Megalin)
  • Length: 4655  
  • Mass: 521958
  • Tissue specificity: Expressed in first and third trimester cytotrophoblasts in the placenta (at protein level) (PubMed
• Sequence:

  MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQ
  SEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQL
  TCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGY
  QFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
  TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEE
  GYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFS
  VDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLF
  FSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
  IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCV
  LSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDA
  QDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYL
  NNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
  GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACN
  QPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDD
  CHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKN
  WVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
  IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSY
  FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG
  NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDG
  RTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
  RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH
  HPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTL
  FEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSC
  VCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
  IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIG
  ITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG
  TDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNN
  MNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
  DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLR
  INTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYW
  VDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRD
  VTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
  LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDW
  ITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSL
  VMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSG
  QIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
  GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC
  LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGD
  NSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWIC
  DGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
  GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC
  PPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC
  VDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEG
  LDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
  GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYT
  NDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHR
  PFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKC
  IPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
  CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSA
  HLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD
  EENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLD
  ASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
  EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENIC
  EQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAE
  GSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFES
  GRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
  WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPY
  SLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYS
  CACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAV
  AVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
  DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGT
  QVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVK
  EDSEV

• Structural information:
  • Protein Domains: (27..6-)
    A (/note="LDL-receptor-class)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00124-)
    (66..10-)
    A (/note="LDL-receptor-class)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00124-)
    (107..14-)
    A (/note="LDL-receptor-class)
    (/evid-)
  • Interpro: IPR011042  IPR026823  IPR001881  IPR013032  IPR000742   IPR000152  IPR018097  IPR009030  IPR036055  IPR023415  IPR000033  IPR002172  IPR019825  
  • Prosite: PS00010 PS00022 PS01186 PS50026 PS01187 PS01209 PS50068 PS51120
  • CDD: cd00112
  • PDB: 2M0P
  • PDBsum: 2M0P
  • STRING: ENSP00000263816
• Other Databases: GeneCards:  LRP2  Malacards:  LRP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0044321	response to leptin	IDA	biological process
GO:0140318	protein transporter activity	ISS	molecular function
GO:0015031	protein transport	IDA	biological process
GO:0051087	chaperone binding	ISS	molecular function
GO:0051087	chaperone binding	IPI	molecular function
GO:0031994	insulin-like growth factor I binding	ISS	molecular function
GO:0006898	receptor-mediated endocytosis	ISS	biological process
GO:0043066	negative regulation of apoptotic process	IGI	biological process
GO:1905167	positive regulation of lysosomal protein catabolic process	ISS	biological process
GO:0045056	transcytosis	ISS	biological process
GO:0150104	transport across blood-brain barrier	NAS	biological process
GO:0150104	transport across blood-brain barrier	NAS	biological process
GO:0071363	cellular response to growth factor stimulus	ISS	biological process
GO:0051897	positive regulation of protein kinase B signaling	IGI	biological process
GO:0097242	amyloid-beta clearance	ISS	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005768	endosome	IEA	cellular component
GO:0017124	SH3 domain binding	IEA	molecular function
GO:0005905	clathrin-coated pit	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0007605	sensory perception of sound	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007399	nervous system development	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0006897	endocytosis	TAS	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006898	receptor-mediated endocytosis	TAS	biological process
GO:0005764	lysosome	TAS	cellular component
GO:0043235	receptor complex	IDA	cellular component
GO:0001523	retinoid metabolic process	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0042359	vitamin D metabolic process	TAS	biological process
GO:0061024	membrane organization	TAS	biological process
GO:0140058	neuron projection arborization	IEA	biological process
GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	IEA	biological process
GO:0060976	coronary vasculature development	IEA	biological process
GO:0050769	positive regulation of neurogenesis	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0005905	clathrin-coated pit	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0003148	outflow tract septum morphogenesis	IEA	biological process
GO:0003139	secondary heart field specification	IEA	biological process
GO:1904447	folate import across plasma membrane	IEA	biological process
GO:0061156	pulmonary artery morphogenesis	IEA	biological process
GO:0060982	coronary artery morphogenesis	IEA	biological process
GO:0060068	vagina development	IEA	biological process
GO:0044321	response to leptin	IEA	biological process
GO:0035904	aorta development	IEA	biological process
GO:0031526	brush border membrane	IEA	cellular component
GO:0030900	forebrain development	IEA	biological process
GO:0030514	negative regulation of BMP signaling pathway	IEA	biological process
GO:0030139	endocytic vesicle	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0008584	male gonad development	IEA	biological process
GO:0008283	cell population proliferation	IEA	biological process
GO:0007605	sensory perception of sound	IEA	biological process
GO:0007507	heart development	IEA	biological process
GO:0006898	receptor-mediated endocytosis	IEA	biological process
GO:0006766	vitamin metabolic process	IEA	biological process
GO:0005903	brush border	IEA	cellular component
GO:0003281	ventricular septum development	IEA	biological process
GO:0003223	ventricular compact myocardium morphogenesis	IEA	biological process
GO:0001843	neural tube closure	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0031904	endosome lumen	IEA	cellular component
GO:0005905	clathrin-coated pit	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0005509	calcium ion binding	IDA	molecular function
GO:0016324	apical plasma membrane	IDA	cellular component
GO:0006898	receptor-mediated endocytosis	IDA	biological process
GO:0030001	metal ion transport	IDA	biological process
GO:0005765	lysosomal membrane	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0007605	sensory perception of sound	ISS	biological process
GO:0060982	coronary artery morphogenesis	ISS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003148	outflow tract septum morphogenesis	ISS	biological process
GO:0003139	secondary heart field specification	ISS	biological process
GO:0016324	apical plasma membrane	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0061156	pulmonary artery morphogenesis	ISS	biological process
GO:0003223	ventricular compact myocardium morphogenesis	ISS	biological process
GO:0016324	apical plasma membrane	ISS	cellular component
GO:1904447	folate import across plasma membrane	ISS	biological process
GO:0006898	receptor-mediated endocytosis	ISS	biological process
GO:0031526	brush border membrane	ISS	cellular component
GO:0008144	drug binding	ISS	molecular function
GO:0008584	male gonad development	ISS	biological process
GO:0060068	vagina development	ISS	biological process
GO:0009897	external side of plasma membrane	ISS	cellular component
GO:0140058	neuron projection arborization	ISS	biological process
GO:0030425	dendrite	ISS	cellular component
GO:0030424	axon	ISS	cellular component
GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	ISS	biological process
GO:0030514	negative regulation of BMP signaling pathway	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0001843	neural tube closure	ISS	biological process
GO:0050769	positive regulation of neurogenesis	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04918	Thyroid hormone synthesis
hsa04340	Hedgehog signaling pathway
hsa04979	Cholesterol metabolism

Diseases

Associated diseases	References
Donnai-Barrow syndrome	KEGG:H00886
Donnai-Barrow syndrome	KEGG:H00886
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)