• Gene id: 401466

Gene Summary

• Gene Symbol: RBIS   Gene   UCSC   Ensembl
• Aliases: C8orf59
• Gene name: ribosomal biogenesis factor
• Alternate names: ribosomal biogenesis factor, ribosome biogenesis factor identified in screen, uncharacterized protein C8orf59,
• Gene location: 8q21.2 (85221078: 85214047)     Exons: 6     NC_000008.11
• OMIM: 0

Protein Summary

• Protein general information: Q8N0T1  
  • Name: Ribosomal biogenesis factor
  • Length: 100  
  • Mass: 11456
• Sequence:

  MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEEKVNRVNKAFVNVQKELAHFAKSISLEPLQK
  ELIPQQRHESKPVNVDEATRLMALL

• Structural information:
  • Interpro: IPR031389  
  • STRING: ENSP00000484492
• Other Databases: GeneCards:  RBIS  Malacards:  RBIS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005730	nucleolus	IDA	cellular component
GO:0042254	ribosome biogenesis	IMP	biological process
GO:0042254	ribosome biogenesis	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray