Male Infertility Database

Search Result

Gene id

3981

Gene Summary SNPs Protein Summary Gene ontology Diseases PubMed

Gene Summary

Gene Symbol

LIG4 Gene UCSC Ensembl

Aliases

LIG4S

Gene name

DNA ligase 4

Alternate names

DNA ligase 4, DNA joinase, DNA ligase IV, DNA repair enzyme, ligase IV, DNA, ATP-dependent, polydeoxyribonucleotide synthase [ATP] 4, polynucleotide ligase, sealase,

Gene location

13q33.3 (108218367: 108207441) Exons: 6 NC_000013.11

Gene summary(Entrez)

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonh

OMIM

601837

SNPs

rs1805388

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000013.11   g.108211243G>A
NC_000013.10   g.108863591G>A
NG_007396.1   g.9292C>T
NM_002312.3   c.26C>T
NM_001352599.2   c.26C>T
NM_001352599.1   c.26C>T
NM_001352598.2   c.26C>T
NM_001352598.1   c.26C>T
NM_001352600.2   c.26C>T
NM_001352600.1   c.26C>T
NM_001352601.2

Protein Summary

Protein general information

P49917

Name: DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)

Length: 911 Mass: 103,971

Tissue specificity: Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). {ECO

Sequence

MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQL
ERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVND
LLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVC
RQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNK
KLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKI
KPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKY
WKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPK
PDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPST
KEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAV
INDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

Structural information

Protein Domains	BRCT (654-743) BRCT (808-911)
Interpro:	IPR001357 IPR036420 IPR000977 IPR012309 IPR012310 IPR016059 IPR012308 IPR021536 IPR036599 IPR029710 IPR012340
Prosite:	PS50172 PS00697 PS00333 PS50160
CDD:	cd00027
PDB:	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
PDBsum:	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
DIP:	37958
MINT:
STRING:	ENSP00000349393

Other Databases

GeneCards: LIG4 Malacards: LIG4

Gene ontology

Expand All | Collapse All

GO accession	Term name	Evidence code	Go category
GO:0000012	single strand break repai r	IDA	biological process
GO:0000784	nuclear chromosome, telom eric region	IC	cellular component
GO:0000793	condensed chromosome	IDA	cellular component
GO:0001701	in utero embryonic develo pment	ISS	biological process
GO:0002328	pro-B cell differentiatio n	ISS	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0003909	DNA ligase activity	IDA	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	ISS	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	IDA	cellular component
GO:0006266	DNA ligation	IDA	biological process
GO:0006297	nucleotide-excision repai r, DNA gap filling	IDA	biological process
GO:0006302	double-strand break repai r	ISS	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	ISS	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IGI	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IMP	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	TAS	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0007417	central nervous system de velopment	ISS	biological process
GO:0008022	protein C-terminus bindin g	IPI	molecular function
GO:0008283	cell proliferation	ISS	biological process
GO:0010165	response to X-ray	IMP	biological process
GO:0010332	response to gamma radiati on	ISS	biological process
GO:0016874	ligase activity	IDA	molecular function
GO:0032807	DNA ligase IV complex	IMP	cellular component
GO:0033077	T cell differentiation in thymus	ISS	biological process
GO:0033151	V(D)J recombination	IDA	biological process
GO:0033152	immunoglobulin V(D)J reco mbination	IBA	biological process
GO:0033153	T cell receptor V(D)J rec ombination	ISS	biological process
GO:0035019	somatic stem cell populat ion maintenance	ISS	biological process
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological process
GO:0045190	isotype switching	ISS	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0048146	positive regulation of fi broblast proliferation	ISS	biological process
GO:0050769	positive regulation of ne urogenesis	ISS	biological process
GO:0051102	DNA ligation involved in DNA recombination	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	IDA	biological process
GO:0051276	chromosome organization	ISS	biological process
GO:0051301	cell division	IEA	biological process
GO:0051402	neuron apoptotic process	ISS	biological process
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0071285	cellular response to lith ium ion	IEA	biological process
GO:0071897	DNA biosynthetic process	IEA	biological process
GO:0075713	establishment of integrat ed proviral latency	TAS	biological process
GO:0097680	double-strand break repai r via classical nonhomolo gous end joining	IMP	biological process
GO:2001252	positive regulation of ch romosome organization	IMP	biological process
GO:0006273	lagging strand elongation	IBA	biological process
GO:0000012	single strand break repai r	IDA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000784	nuclear chromosome, telom eric region	IC	cellular component
GO:0000793	condensed chromosome	IDA	cellular component
GO:0001701	in utero embryonic develo pment	IEA	biological process
GO:0001701	in utero embryonic develo pment	ISS	biological process
GO:0002328	pro-B cell differentiatio n	IEA	biological process
GO:0002328	pro-B cell differentiatio n	ISS	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0003677	DNA binding	IDA	molecular function
GO:0003909	DNA ligase activity	IEA	molecular function
GO:0003909	DNA ligase activity	IDA	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003910	DNA ligase (ATP) activity	IEA	molecular function
GO:0003910	DNA ligase (ATP) activity	IEA	molecular function
GO:0003910	DNA ligase (ATP) activity	IEA	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	IEA	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	ISS	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	IDA	cellular component
GO:0006260	DNA replication	IEA	biological process
GO:0006266	DNA ligation	IEA	biological process
GO:0006266	DNA ligation	IDA	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0006297	nucleotide-excision repai r, DNA gap filling	IDA	biological process
GO:0006302	double-strand break repai r	IEA	biological process
GO:0006302	double-strand break repai r	ISS	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IEA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	ISS	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IGI	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IMP	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	TAS	biological process
GO:0006310	DNA recombination	IEA	biological process
GO:0006310	DNA recombination	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0007417	central nervous system de velopment	IEA	biological process
GO:0007417	central nervous system de velopment	ISS	biological process
GO:0008022	protein C-terminus bindin g	IPI	molecular function
GO:0008283	cell proliferation	IEA	biological process
GO:0008283	cell proliferation	ISS	biological process
GO:0010165	response to X-ray	IMP	biological process
GO:0010212	response to ionizing radi ation	IEA	biological process
GO:0010332	response to gamma radiati on	IEA	biological process
GO:0010332	response to gamma radiati on	ISS	biological process
GO:0016874	ligase activity	IEA	molecular function
GO:0016874	ligase activity	IDA	molecular function
GO:0032807	DNA ligase IV complex	IMP	cellular component
GO:0033077	T cell differentiation in thymus	IEA	biological process
GO:0033077	T cell differentiation in thymus	ISS	biological process
GO:0033151	V(D)J recombination	IEA	biological process
GO:0033151	V(D)J recombination	IDA	biological process
GO:0033152	immunoglobulin V(D)J reco mbination	IEA	biological process
GO:0033152	immunoglobulin V(D)J reco mbination	IBA	biological process
GO:0033153	T cell receptor V(D)J rec ombination	IEA	biological process
GO:0033153	T cell receptor V(D)J rec ombination	ISS	biological process
GO:0035019	somatic stem cell populat ion maintenance	IEA	biological process
GO:0035019	somatic stem cell populat ion maintenance	ISS	biological process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological process
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological process
GO:0045190	isotype switching	IEA	biological process
GO:0045190	isotype switching	ISS	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0048146	positive regulation of fi broblast proliferation	IEA	biological process
GO:0048146	positive regulation of fi broblast proliferation	ISS	biological process
GO:0050769	positive regulation of ne urogenesis	IEA	biological process
GO:0050769	positive regulation of ne urogenesis	ISS	biological process
GO:0051102	DNA ligation involved in DNA recombination	IEA	biological process
GO:0051102	DNA ligation involved in DNA recombination	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	IEA	biological process
GO:0051103	DNA ligation involved in DNA repair	IEA	biological process
GO:0051103	DNA ligation involved in DNA repair	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	IDA	biological process
GO:0051276	chromosome organization	IEA	biological process
GO:0051276	chromosome organization	ISS	biological process
GO:0051301	cell division	IEA	biological process
GO:0051402	neuron apoptotic process	IEA	biological process
GO:0051402	neuron apoptotic process	ISS	biological process
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0071285	cellular response to lith ium ion	IEA	biological process
GO:0071897	DNA biosynthetic process	IEA	biological process
GO:0075713	establishment of integrat ed proviral latency	TAS	biological process
GO:0097680	double-strand break repai r via classical nonhomolo gous end joining	IMP	biological process
GO:2001252	positive regulation of ch romosome organization	IMP	biological process
GO:0006273	lagging strand elongation	IBA	biological process
GO:0000012	single strand break repai r	IDA	biological process
GO:0000784	nuclear chromosome, telom eric region	IC	cellular component
GO:0000793	condensed chromosome	IDA	cellular component
GO:0001701	in utero embryonic develo pment	ISS	biological process
GO:0002328	pro-B cell differentiatio n	ISS	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0003909	DNA ligase activity	IDA	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003909	DNA ligase activity	TAS	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0003910	DNA ligase (ATP) activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	ISS	cellular component
GO:0005958	DNA-dependent protein kin ase-DNA ligase 4 complex	IDA	cellular component
GO:0006266	DNA ligation	IDA	biological process
GO:0006297	nucleotide-excision repai r, DNA gap filling	IDA	biological process
GO:0006302	double-strand break repai r	ISS	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006302	double-strand break repai r	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	ISS	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IDA	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IGI	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	IMP	biological process
GO:0006303	double-strand break repai r via nonhomologous end j oining	TAS	biological process
GO:0007417	central nervous system de velopment	ISS	biological process
GO:0008022	protein C-terminus bindin g	IPI	molecular function
GO:0008283	cell proliferation	ISS	biological process
GO:0010165	response to X-ray	IMP	biological process
GO:0010332	response to gamma radiati on	ISS	biological process
GO:0016874	ligase activity	IDA	molecular function
GO:0032807	DNA ligase IV complex	IMP	cellular component
GO:0033077	T cell differentiation in thymus	ISS	biological process
GO:0033151	V(D)J recombination	IDA	biological process
GO:0033152	immunoglobulin V(D)J reco mbination	IBA	biological process
GO:0033153	T cell receptor V(D)J rec ombination	ISS	biological process
GO:0035019	somatic stem cell populat ion maintenance	ISS	biological process
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological process
GO:0045190	isotype switching	ISS	biological process
GO:0048146	positive regulation of fi broblast proliferation	ISS	biological process
GO:0050769	positive regulation of ne urogenesis	ISS	biological process
GO:0051102	DNA ligation involved in DNA recombination	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	ISS	biological process
GO:0051103	DNA ligation involved in DNA repair	IDA	biological process
GO:0051276	chromosome organization	ISS	biological process
GO:0051402	neuron apoptotic process	ISS	biological process
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0070419	nonhomologous end joining complex	IDA	cellular component
GO:0075713	establishment of integrat ed proviral latency	TAS	biological process
GO:0097680	double-strand break repai r via classical nonhomolo gous end joining	IMP	biological process
GO:2001252	positive regulation of ch romosome organization	IMP	biological process
GO:0006273	lagging strand elongation	IBA	biological process

Diseases

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Associated diseases	References
Cancer	GAD: 12036913
Cancer (bladder)	GAD: 19692168
Cancer (brain)	GAD: 20150366
Cancer (lung)	GAD: 15609317
Cancer (lymphoma)	GAD: 18830263
Cancer (melanoma)	GAD: 15126335
Cancer (myeloma)	GAD: 20568250
Cancer (ovarian)	GAD: 19127255
Cancer (pancreatic)	GAD: 19147782
Cancer (Papilary)	GAD: 19092295
Cancer (prostate)	GAD: 16638864
Cancer (thyroid)	GAD: 20811692
Cancer (Adenocarcinoma)	GAD: 19251090
Cancer (cervical)	GAD: 20400235
Cancer (colorectal)	GAD: 19536092
Cancer (epithelial ovarian)	GAD: 19064572
Cancer (esophageal)	GAD: 20453000
Cancer (leukemia)	GAD: 19074885
Cancer (breast)	GAD: 12036913
Hodgkin disease	GAD: 19573080
Multiple sclerosis	GAD: 20522537
Immunodeficiency	KEGG: H00094
Carotid artery diseases	GAD: 17903303
Attention deficit hyperactivity disorder (ADHD)	GAD: 18951430
Infertility	MIK: 23630330
Male factor infertility	MIK: 23630330
Chronic renal failure	GAD: 21085059
Male infertility	MIK: 28991497
Teratozoospermia	MIK: 17327269

PubMed references

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PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
23630330	Impaired i nfertility	LIG4 rs1805388, RAG1 rs2227973�	Chinese	1160 (580 infer tility cases, 5 80 controls)	Male infertility	XRCC3 XRCC2 �BRCA2 RAG1 XRCC5 LIG4 XRCC4 and ATM	Show abstract
23630330	Male infer tility	RAG1 rs2227973 (A>G, K820R), LIG4 rs1805388	Chinese	1160 (580 infer tility cases, 5 80 controls)	Male infertility	XRCC3 XRCC2 BRCA2 RAG1 XRCC5 LIG4 XRCC4 and�ATM	Show abstract
23630330	Male infer tility	LIG4 rs1805388 (Ex2+54C>T, Thr9Ile), RAG1 rs2227973 (A>G, K820R)	Chinese	1060 (580 infer tility cases, 5 80 controls)	Male infertility	RAG1 LIG4	Show abstract
28991497	Idiopathic male infe rtility	T9I		382 (191 fertil e, 191 infertil e men)	Male infertility		Show abstract
17327269	Teratozoos permia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)	Show abstract
17327269	Teratozoos permia			19 (6 controls , 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)	Show abstract
31037746	Spermatoge nic defect s			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

SNPs

Protein Summary

Gene ontology

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Diseases

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PubMed references

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

SNPs

Protein Summary

Gene ontology

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Diseases Expand All | Collapse All

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PubMed references

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Diseases

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