• Gene id: 3964

Gene Summary

• Gene Symbol: LGALS8   Gene   UCSC   Ensembl
• Aliases: Gal-8, PCTA-1, PCTA1, Po66-CBP
• Gene name: galectin 8
• Alternate names: galectin-8, Po66 carbohydrate binding protein, galectin-8g, lectin, galactoside-binding, soluble, 8, po66 carbohydrate-binding protein, prostate carcinoma tumor antigen 1,
• Gene location: 1q43 (75109220: 75094431)     Exons: 10     NC_000010.11
• Gene summary(Entrez): This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation
• OMIM: 606099

Protein Summary

• Protein general information: O00214  
  • Name: Galectin 8 (Gal 8) (Po66 carbohydrate binding protein) (Po66 CBP) (Prostate carcinoma tumor antigen 1) (PCTA 1)
  • Length: 317  
  • Mass: 35808
  • Tissue specificity: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
• Sequence:

  MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGC
  IVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIG
  FSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKD
  IALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSI
  DTLEINGDIHLLEVRSW

• Structural information:
  • Protein Domains: (19..15-)
    (/note="Galectin-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00639-)
    (187..31-)
    (/note="Galectin-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00639"-)
  • Interpro: IPR013320  IPR030638  IPR001079  
  • Prosite: PS51304
  • CDD: cd00070
  • PDB: 2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG
  • PDBsum: 2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG
• Other Databases: GeneCards:  LGALS8  Malacards:  LGALS8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005178	integrin binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0030246	carbohydrate binding	IBA	molecular function
GO:1904977	lymphatic endothelial cell migration	IBA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:1904977	lymphatic endothelial cell migration	IDA	biological process
GO:0005178	integrin binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0098586	cellular response to virus	IMP	biological process
GO:0098792	xenophagy	IMP	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0006914	autophagy	IEA	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0030246	carbohydrate binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0098792	xenophagy	IMP	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0030246	carbohydrate binding	IDA	molecular function
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)