• Gene id: 3939

Gene Summary

• Gene Symbol: LDHA   Gene   UCSC   Ensembl
• Aliases: GSD11, HEL-S-133P, LDHM, PIG19
• Gene name: lactate dehydrogenase A
• Alternate names: L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, cell proliferation-inducing gene 19 protein, epididymis secretory sperm binding protein Li 133P, lactate dehydrogenase M, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59,
• Gene location: 11p15.1 (18394388: 18408217)     Exons: 9     NC_000011.10
• Gene summary(Entrez): The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations i
• OMIM: 150000

Protein Summary

• Protein general information: P00338  
  • Name: L lactate dehydrogenase A chain (LDH A) (EC 1.1.1.27) (Cell proliferation inducing gene 19 protein) (LDH muscle subunit) (LDH M) (Renal carcinoma antigen NY REN 59)
  • Length: 332  
  • Mass: 36,689
• Sequence:

  MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTP
  KIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKI
  SGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKE
  QWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
  SDLVKVTLTSEEEARLKKSADTLWGIQKELQF

• Structural information:
  • Interpro: IPR001557  IPR011304  IPR018177  IPR022383  IPR001236   IPR015955  IPR036291  
  • Prosite: PS00064
  • PDB: 1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L
  • PDBsum: 1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L
  • STRING: ENSP00000445175
• Other Databases: GeneCards:  LDHA  Malacards:  LDHA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001666	response to hypoxia	IEA	biological process
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0004459	L-lactate dehydrogenase activity	NAS	molecular function
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006089	lactate metabolic process	IEA	biological process
GO:0006090	pyruvate metabolic process	TAS	biological process
GO:0006096	glycolytic process	NAS	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0009749	response to glucose	IEA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0019674	NAD metabolic process	IEA	biological process
GO:0019900	kinase binding	IEA	molecular function
GO:0021762	substantia nigra development	IEP	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042542	response to hydrogen peroxide	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043627	response to estrogen	IEA	biological process
GO:0048569	post-embryonic animal organ development	IEA	biological process
GO:0051287	NAD binding	IEA	molecular function
GO:0051591	response to cAMP	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0001666	response to hypoxia	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004457	lactate dehydrogenase activity	IEA	molecular function
GO:0004459	L-lactate dehydrogenase activity	IEA	molecular function
GO:0004459	L-lactate dehydrogenase activity	IEA	molecular function
GO:0004459	L-lactate dehydrogenase activity	IEA	molecular function
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0004459	L-lactate dehydrogenase activity	NAS	molecular function
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0004459	L-lactate dehydrogenase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006089	lactate metabolic process	IEA	biological process
GO:0006090	pyruvate metabolic process	TAS	biological process
GO:0006096	glycolytic process	NAS	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0009749	response to glucose	IEA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	molecular function
GO:0019674	NAD metabolic process	IEA	biological process
GO:0019752	carboxylic acid metabolic process	IEA	biological process
GO:0019900	kinase binding	IEA	molecular function
GO:0021762	substantia nigra development	IEP	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042542	response to hydrogen peroxide	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043627	response to estrogen	IEA	biological process
GO:0048569	post-embryonic animal organ development	IEA	biological process
GO:0051287	NAD binding	IEA	molecular function
GO:0051591	response to cAMP	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0004459	L-lactate dehydrogenase activity	NAS	molecular function
GO:0004459	L-lactate dehydrogenase activity	EXP	molecular function
GO:0004459	L-lactate dehydrogenase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006090	pyruvate metabolic process	TAS	biological process
GO:0006096	glycolytic process	NAS	biological process
GO:0016020	membrane	IDA	cellular component
GO:0021762	substantia nigra development	IEP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04066	HIF-1 signaling pathway
hsa04922	Glucagon signaling pathway
hsa05230	Central carbon metabolism in cancer

Diseases

Associated diseases	References
Glycogen storage disease	KEGG: H00069
Muscle glycogen storage disease	KEGG: H01762
Panic disorder	GAD: 12555229
Male factor infertility	MIK: 9052941
Oligozoospermia	MIK: 1879960
Oligozoospermia	MIK: 1879960
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
1879960	Oligozoospermic			222 (74 oligozoospermic patients, 148 normospermic men)	Male infertility	LDH LDH-X
9052941	Oligospermic			145 (50 oligospermic, 95 normospermic)	Male infertility	LDH CK
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)