• Gene id: 389643

Gene Summary

• Gene Symbol: NUGGC   Gene   UCSC   Ensembl
• Aliases: C8orf80, HMFN0672, SLIP-GC
• Gene name: nuclear GTPase, germinal center associated
• Alternate names: nuclear GTPase SLIP-GC, GTPase SLIP-GC, speckled-like pattern in the germinal center,
• Gene location: 8p21.1 (3625014: 3630126)     Exons: 5     NC_000001.11

Protein Summary

• Protein general information: Q68CJ6  
  • Name: Nuclear GTPase SLIP GC (EC 3.6.1. ) (Speckled like pattern in the germinal center)
  • Length: 796  
  • Mass: 91132
  • Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell. {ECO
• Sequence:

  MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRVLSNTYQKLIQSVFLD
  DSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAIIQQAMFLPVSGESICTSCIVQVSSGCCVQY
  EAKIHLLSDQEWREELKNLTKLLHRTEELSREEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKI
  PTSRVITLKAEEAEELSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSK
  RDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLHLPEYLRERKAGNQAI
  QSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSL
  LDKKKRTVTKYVTEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTAR
  TSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALM
  PHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLTASVQSDLKLCYEEAA
  QITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQGDGLYKELADV
  GSEYKEMEKLHRSLREVAENARLRKGMQEFLLRASPSKAGPPGTSL

• Structural information:
  • Interpro: IPR022812  IPR027417  
  • STRING: ENSP00000408697
• Other Databases: GeneCards:  NUGGC  Malacards:  NUGGC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003924	GTPase activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0016607	nuclear speck	IEA	cellular component
GO:0071222	cellular response to lipopolysaccharide	IDA	biological process
GO:0003924	GTPase activity	IDA	molecular function
GO:0033262	regulation of nuclear cell cycle DNA replication	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)