• Gene id: 389072

Gene Summary

• Gene Symbol: PLEKHM3   Gene   UCSC   Ensembl
• Aliases: DAPR, PLEKHM1L
• Gene name: pleckstrin homology domain containing M3
• Alternate names: pleckstrin homology domain-containing family M member 3, PH domain-containing family M member 3, differentiation associated protein,
• Gene location: 2q33.3 (208025674: 207821287)     Exons: 13     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q6ZWE6  
  • Name: Pleckstrin homology domain containing family M member 3 (PH domain containing family M member 3) (Differentiation associated protein)
  • Length: 761  
  • Mass: 87166
• Sequence:

  MEALEVDDISPALEVTEEFFSTLDSNLEKAVQQAEVYGIQEVPELVGHEVLSNITDNGAMRNVTSLGKGGMIWDH
  CKSRLLETKAQNVFPAKEQFMVQRGTTPDNLSWMEQKEASTFNFFNICQRRRDRPRSVNDLLDETSTFKPGHARS
  RSDITQVDWRVVLKTTPLQQQQQQQPLLQGPHVTRPSFLLPSPNKIEDAQGNTEHKQTFPNILKKGYLEIRKDHD
  SYWQSCYAELSPYNLYFYSLDSSGNQNLYATYQLSHFQSISVLGNLEARMVDTVLYDNTQLQLKAESPWEALDWG
  QKLWEVVHAAVPGYMGRQNELTISPGLGHHDDYTQNHSFQKKTSGLLPPSPVLDSSKQYQNILKSGTLYRLTVQN
  NWKAFTFVLSRAYLMAFQPGKLDEDPLLSYNVDVCLAVQMDNLDGCDSCFQVIFPQDVLRLRAETRQRAQEWMEA
  LKIAANVARSSEQNLQVTLRNKPKDQMGGHELRKNKRQSVTTSFLSILTTLSLERGLTAQSFKCAGCQRSIGLSN
  GKAKVCNYSGWYYCSSCHVDDSFLIPARIVHNWDTSKYKVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAA
  VLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSHVYSCS
  LCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEA
  CTMFELSYQNT

• Structural information:
  • Protein Domains: (211..30-)
    (/note="PH-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (361..45-)
    (/note="PH-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"-)
  • Interpro: IPR011993  IPR001849  IPR037812  IPR025258  
  • Prosite: PS50003
  • CDD: cd14674
  • STRING: ENSP00000417003
• Other Databases: GeneCards:  PLEKHM3  Malacards:  PLEKHM3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005794	Golgi apparatus	ISS	cellular component
GO:0045445	myoblast differentiation	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0045445	myoblast differentiation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)