Gene id |
387332 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
TBPL2 Gene UCSC Ensembl |
Aliases |
TBP2, TRF3 |
Gene name |
TATA-box binding protein like 2 |
Alternate names |
TATA box-binding protein-like protein 2, TATA box-binding protein-related factor 3, TBP-like protein 2, TBP-related factor 3, |
Gene location |
14q22.3 (55440544: 55414209) Exons: 7 NC_000014.9
|
OMIM |
608964 |
Protein Summary
|
Protein general information
| Q6SJ96
Name: TATA box binding protein like protein 2 (TBP like protein 2) (TATA box binding protein related factor 3) (TBP related factor 3)
Length: 375 Mass: 41524
Tissue specificity: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes. {ECO
|
Sequence |
MASAPWPERVPRLLAPRLPSYPPPPPTVGLRSMEQEETYLELYLDQCAAQDGLAPPRSPLFSPVVPYDMYILNAS NPDTAFNSNPEVKETSGDFSSVDLSFLPDEVTQENKDQPVISKHETEENSESQSPQSRLPSPSEQDVGLGLNSSS LSNSHSQLHPGDTDSVQPSPEKPNSDSLSLASITPMTPMTPISECCGIVPQLQNIVSTVNLACKLDLKKIALHAK NAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFKIQNMVGSCD VRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKA
|
Structural information |
|
Other Databases |
GeneCards: TBPL2 Malacards: TBPL2 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0006366 |
transcription by RNA poly merase II
|
IBA |
biological process |
GO:0005669 |
transcription factor TFII D complex
|
IBA |
cellular component |
GO:0003700 |
DNA-binding transcription factor activity
|
IBA |
molecular function |
GO:0001016 |
RNA polymerase III transc ription regulatory region sequence-specific DNA bi nding
|
IBA |
molecular function |
GO:0000979 |
RNA polymerase II core pr omoter sequence-specific DNA binding
|
IBA |
molecular function |
GO:0000978 |
RNA polymerase II cis-reg ulatory region sequence-s pecific DNA binding
|
IBA |
molecular function |
GO:0000126 |
transcription factor TFII IB complex
|
IBA |
cellular component |
GO:0070898 |
RNA polymerase III preini tiation complex assembly
|
IBA |
biological process |
GO:0008134 |
transcription factor bind ing
|
IBA |
molecular function |
GO:0005667 |
transcription regulator c omplex
|
IBA |
cellular component |
GO:0006352 |
DNA-templated transcripti on, initiation
|
IEA |
biological process |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0007275 |
multicellular organism de velopment
|
IEA |
biological process |
GO:0003700 |
DNA-binding transcription factor activity
|
IEA |
molecular function |
GO:0045892 |
negative regulation of tr anscription, DNA-template d
|
IEA |
biological process |
GO:0003677 |
DNA binding
|
IEA |
molecular function |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005634 |
nucleus
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IDA |
cellular component |
GO:0005634 |
nucleus
|
IDA |
cellular component |
|
|
|
|
Associated diseases |
References |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
13 (5 controls, 8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|