|
Gene id |
3837 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
KPNB1 Gene UCSC Ensembl |
|
Aliases |
IMB1, IPO1, IPOB, Impnb, NTF97 |
|
Gene name |
karyopherin subunit beta 1 |
|
Alternate names |
importin subunit beta-1, PTAC97, importin 1, importin 90, importin beta-1 subunit, karyopherin (importin) beta 1, nuclear factor p97, pore targeting complex 97 kDa subunit, |
|
Gene location |
17q21.32 (47649918: 47685504) Exons: 23 NC_000003.12
|
|
Gene summary(Entrez) |
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a het
|
|
OMIM |
602738 |
|
| Pathway id | Pathway name |
|---|
| hsa03013 | RNA transport | |
|
| Associated diseases |
References |
| Cancer (breast) | GAD: 18398821 |
| Spermatogenesis defects | MIK: 21900684 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Male factor infertility | MIK: 29961538 |
| Role in mammalian spermatogenesis | MIK: 21900684 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 21900684 |
Role in ma
mmalian sp
ermatogene
sis
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 29961538 |
Male facto
r infertil
ity
|
|
|
318 (128 couple
s presenting wi
th OAT (MF) and
118 maternal a
ge-matched cont
rol (no MF) sub
jects undergoin
g infertility t
reatment, 72 su
rplus cryoprese
rved blastocyst
s)
|
Male infertility |
RNA-seq
|
Show abstract |
|