• Gene id: 3833

Gene Summary

• Gene Symbol: KIFC1   Gene   UCSC   Ensembl
• Aliases: HSET, KNSL2
• Gene name: kinesin family member C1
• Alternate names: kinesin-like protein KIFC1, kinesin-like 2, kinesin-like protein 2, kinesin-related protein HSET,
• Gene location: 6p21.32 (248273813: 248272851)     Exons: 1     NC_000001.11
• OMIM: 603763

Protein Summary

• Protein general information: Q9BW19  
  • Name: Kinesin like protein KIFC1 (Kinesin like protein 2) (Kinesin related protein HSET)
  • Length: 673  
  • Mass: 73748
• Sequence:

  MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATTKITTSHPRVPSLTTV
  PQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAEL
  KRCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEG
  LVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
  HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFD
  RVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSG
  QGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRA
  VARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
  LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK

• Structural information:
  • Protein Domains: (310..66-)
    (/note="Kinesin-motor)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00283"-)
  • Interpro: IPR027640  IPR019821  IPR001752  IPR036961  IPR027417  
  • Prosite: PS00411 PS50067
  • PDB: 5WDH
  • PDBsum: 5WDH
  • STRING: ENSP00000393963
• Other Databases: GeneCards:  KIFC1  Malacards:  KIFC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0090307	mitotic spindle assembly	IBA	biological process
GO:0008017	microtubule binding	IBA	molecular function
GO:0007018	microtubule-based movement	IBA	biological process
GO:0005871	kinesin complex	IBA	cellular component
GO:0003777	microtubule motor activity	IBA	molecular function
GO:0072686	mitotic spindle	IBA	cellular component
GO:0016887	ATPase activity	IBA	molecular function
GO:0005874	microtubule	IBA	cellular component
GO:0005815	microtubule organizing center	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0007080	mitotic metaphase plate congression	IMP	biological process
GO:0090307	mitotic spindle assembly	IMP	biological process
GO:0003777	microtubule motor activity	IEA	molecular function
GO:0007018	microtubule-based movement	IEA	biological process
GO:0008017	microtubule binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0051301	cell division	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0005819	spindle	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005769	early endosome	IEA	cellular component
GO:0003777	microtubule motor activity	NAS	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0005524	ATP binding	NAS	molecular function
GO:0000070	mitotic sister chromatid segregation	NAS	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)