• Gene id: 3832

Gene Summary

• Gene Symbol: KIF11   Gene   UCSC   Ensembl
• Aliases: EG5, HKSP, KNSL1, MCLMR, TRIP5
• Gene name: kinesin family member 11
• Alternate names: kinesin-like protein KIF11, TR-interacting protein 5, TRIP-5, kinesin-like protein 1, kinesin-like spindle protein HKSP, kinesin-related motor protein Eg5, thyroid receptor-interacting protein 5,
• Gene location: 10q23.33 (92593129: 92655394)     Exons: 22     NC_000010.11
• Gene summary(Entrez): This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome
• OMIM: 188300

Protein Summary

• Protein general information: P52732  
  • Name: Kinesin like protein KIF11 (Kinesin like protein 1) (Kinesin like spindle protein HKSP) (Kinesin related motor protein Eg5) (Thyroid receptor interacting protein 5) (TR interacting protein 5) (TRIP 5)
  • Length: 1056  
  • Mass: 119159
• Sequence:

  MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGAS
  TKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDN
  GTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAA
  TLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
  ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALI
  KEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQC
  KSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQ
  HNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
  SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKEL
  DGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSV
  QENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTR
  TVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
  TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPD
  VDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPL
  RAQINL

• Structural information:
  • Protein Domains: (18..35-)
    (/note="Kinesin-motor)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00283"-)
  • Interpro: IPR025901  IPR027640  IPR019821  IPR001752  IPR036961   IPR027417  
  • Prosite: PS00411 PS50067
  • PDB: 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY
  • PDBsum: 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY
  • DIP: 53686
  • STRING: ENSP00000260731
• Other Databases: GeneCards:  KIF11  Malacards:  KIF11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000922	spindle pole	IDA	colocalizes with
GO:0005876	spindle microtubule	IDA	colocalizes with
GO:0003777	microtubule motor activity	IBA	molecular function
GO:0005871	kinesin complex	IBA	cellular component
GO:0007018	microtubule-based movement	IBA	biological process
GO:0008017	microtubule binding	IBA	molecular function
GO:0090307	mitotic spindle assembly	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0005874	microtubule	IBA	cellular component
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	IBA	molecular function
GO:0016887	ATPase activity	IBA	molecular function
GO:0046602	regulation of mitotic centrosome separation	IMP	biological process
GO:0090307	mitotic spindle assembly	IMP	biological process
GO:0003777	microtubule motor activity	IEA	molecular function
GO:0007018	microtubule-based movement	IEA	biological process
GO:0008017	microtubule binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0051301	cell division	IEA	biological process
GO:0005874	microtubule	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0007049	cell cycle	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0003777	microtubule motor activity	TAS	molecular function
GO:0005819	spindle	TAS	cellular component
GO:0005871	kinesin complex	TAS	cellular component
GO:0007052	mitotic spindle organization	TAS	biological process
GO:0000278	mitotic cell cycle	TAS	biological process
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS	biological process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0007018	microtubule-based movement	TAS	biological process
GO:0051225	spindle assembly	IEA	biological process
GO:0007100	mitotic centrosome separation	IEA	biological process
GO:0000922	spindle pole	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0072686	mitotic spindle	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005874	microtubule	IDA	cellular component
GO:0005819	spindle	IDA	cellular component
GO:0090307	mitotic spindle assembly	IDA	biological process
GO:0016020	membrane	HDA	cellular component
GO:0032991	protein-containing complex	IPI	cellular component
GO:0007051	spindle organization	IMP	biological process
GO:0019901	protein kinase binding	IPI	molecular function

Diseases

Associated diseases	References
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	KEGG:H01876
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	KEGG:H01876
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray