• Gene id: 3802

Gene Summary

• Gene Symbol: KIR2DL1   Gene   UCSC   Ensembl
• Aliases: CD158A, KIR-K64, KIR221, KIR2DL3, NKAT, NKAT-1, NKAT1, p58.1
• Gene name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
• Alternate names: killer cell immunoglobulin-like receptor 2DL1, CD158 antigen-like family member A, KIR2DL protein, KIR2DL1/3DL2, MHC class I NK cell receptor, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, killer inhibitory receptor 2-2-1, natu,
• Gene location: 19q13.42 (54769207: 54784325)     Exons: 11     NC_000019.10
• Gene summary(Entrez): Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the
• OMIM: 604936

Protein Summary

• Protein general information: P43626  
  • Name: Killer cell immunoglobulin like receptor 2DL1 (CD158 antigen like family member A) (MHC class I NK cell receptor) (Natural killer associated transcript 1) (NKAT 1) (p58 natural killer cell receptor clones CL 42/47.11) (p58 NK receptor CL 42/47.11) (p58.1
  • Length: 348  
  • Mass: 38505
  • Tissue specificity: Expressed by NK cells. {ECO
• Sequence:

  MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGE
  HHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCS
  SRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPS
  NSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEV
  TYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

• Structural information:
  • Protein Domains: (42..10-)
    1 (/note="Ig-like-C2-type)
    (142..20-)
    2" (/note="Ig-like-C2-type)
  • Interpro: IPR036179  IPR013783  IPR003599  IPR013151  
  • PDB: 1IM9 1NKR
  • PDBsum: 1IM9 1NKR
  • STRING: ENSP00000336769
• Other Databases: GeneCards:  KIR2DL1  Malacards:  KIR2DL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0038023	signaling receptor activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006955	immune response	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0050776	regulation of immune response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0002769	natural killer cell inhibitory signaling pathway	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04218	Cellular senescence
hsa04650	Natural killer cell mediated cytotoxicity
hsa04612	Antigen processing and presentation
hsa05332	Graft-versus-host disease

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)