• Gene id: 3782

Gene Summary

• Gene Symbol: KCNN3   Gene   UCSC   Ensembl
• Aliases: KCa2.3, SK3, SKCA3, ZLS3, hSK3
• Gene name: potassium calcium-activated channel subfamily N member 3
• Alternate names: small conductance calcium-activated potassium channel protein 3, SKCa 3, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member ,
• Gene location: 1q21.3 (3262132: 3278460)     Exons: 5     NC_000018.10
• Gene summary(Entrez): Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is
• OMIM: 602983

Protein Summary

• Protein general information: Q9UGI6  
  • Name: Small conductance calcium activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)
  • Length: 731  
  • Mass: 81385
• Sequence:

  MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQ
  QQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPG
  GGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSRE
  DNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVI
  ETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAI
  HPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFV
  MKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCL
  LTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKH
  QRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPL
  LIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC

• Structural information:
  • Interpro: IPR004178  IPR036122  IPR015449  IPR013099  
  • STRING: ENSP00000481848
• Other Databases: GeneCards:  KCNN3  Malacards:  KCNN3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043005	neuron projection	IBA	cellular component
GO:0016286	small conductance calcium-activated potassium channel activity	IBA	molecular function
GO:0005516	calmodulin binding	IBA	molecular function
GO:0071805	potassium ion transmembrane transport	IBA	biological process
GO:0043025	neuronal cell body	IBA	cellular component
GO:0006811	ion transport	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0005516	calmodulin binding	IDA	molecular function
GO:0016286	small conductance calcium-activated potassium channel activity	IDA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0016286	small conductance calcium-activated potassium channel activity	IEA	molecular function
GO:0006813	potassium ion transport	IEA	biological process
GO:0015269	calcium-activated potassium channel activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005516	calmodulin binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04911	Insulin secretion
hsa04929	GnRH secretion

Diseases

Associated diseases	References
paranoid schizophrenia	PMID:12007452
Schizophrenia	PMID:9672903
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq