• Gene id: 377841

Gene Summary

• Gene Symbol: ENTPD8   Gene   UCSC   Ensembl
• Aliases: E-NTPDase, GLSR2492, NTPDase-8, UNQ2492
• Gene name: ectonucleoside triphosphate diphosphohydrolase 8
• Alternate names: ectonucleoside triphosphate diphosphohydrolase 8, E-NTPDase 8, liver ecto-ATP-diphosphohydrolase,
• Gene location: 9q34.3 (137441709: 137434363)     Exons: 11     NC_000009.12
• OMIM: 603815

Protein Summary

• Protein general information: Q5MY95  
  • Name: Ectonucleoside triphosphate diphosphohydrolase 8 (E NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5)
  • Length: 495  
  • Mass: 53904
• Sequence:

  MGLSRKEQVFLALLGASGVSGLTALILLLVEATSVLLPTDIKFGIVFDAGSSHTSLFLYQWLANKENGTGVVSQA
  LACQVEGPGISSYTSNAAQAGESLQGCLEEALVLIPEAQHRKTPTFLGATAGMRLLSRKNSSQARDIFAAVTQVL
  GRSPVDFWGAELLAGQAEGAFGWITVNYGLGTLVKYSFTGEWIQPPEEMLVGALDMGGASTQITFVPGGPILDKS
  TQADFRLYGSDYSVYTHSYLCFGRDQMLSRLLVGLVQSRPAALLRHPCYLSGYQTTLALGPLYESPCVHATPPLS
  LPQNLTVEGTGNPGACVSAIRELFNFSSCQGQEDCAFDGVYQPPLRGQFYAFSNFYYTFHFLNLTSRQPLSTVNA
  TIWEFCQRPWKLVEASYPGQDRWLRDYCASGLYILTLLHEGYGFSEETWPSLEFRKQAGGVDIGWTLGYMLNLTG
  MIPADAPAQWRAESYGVWVAKVVFMVLALVAVVGAALVQLFWLQD

• Structural information:
  • Interpro: IPR000407  
  • Prosite: PS01238
  • STRING: ENSP00000360561
• Other Databases: GeneCards:  ENTPD8  Malacards:  ENTPD8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0102486	dCTP phosphohydrolase activity	IEA	molecular function
GO:0102488	dTTP phosphohydrolase activity	IEA	molecular function
GO:0102489	GTP phosphohydrolase activity	IEA	molecular function
GO:0102491	dGTP phosphohydrolase activity	IEA	molecular function
GO:0102490	8-oxo-dGTP phosphohydrolase activity	IEA	molecular function
GO:0102485	dATP phosphohydrolase activity	IEA	molecular function
GO:0102487	dUTP phosphohydrolase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0034656	nucleobase-containing small molecule catabolic process	TAS	biological process
GO:0009124	nucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009133	nucleoside diphosphate biosynthetic process	IEA	biological process
GO:0017110	nucleoside-diphosphatase activity	IEA	molecular function
GO:0017111	nucleoside-triphosphatase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05169	Epstein-Barr virus infection
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq