• Gene id: 374659

Gene Summary

• Gene Symbol: HDDC3   Gene   UCSC   Ensembl
• Aliases: (ppGpp)ase, MESH1
• Gene name: HD domain containing 3
• Alternate names: guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1, HD domain-containing protein 3, metazoan SpoT homolog 1, penta-phosphate guanosine-3'-pyrophosphohydrolase,
• Gene location: 15q26.1 (90932568: 90929967)     Exons: 4     NC_000015.10

Protein Summary

• Protein general information: Q8N4P3  
  • Name: Guanosine 3',5' bis(diphosphate) 3' pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta phosphate guanosine 3' pyrophosphohydrolase) ((ppGpp)ase)
  • Length: 179  
  • Mass: 20329
• Sequence:

  MGSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALLHDTVEDTDTTLDEVE
  LHFGAQVRRLVEEVTDDKTLPKLERKRLQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWA
  AQVVKGLQGTNRQLEEALKHLFKQRGLTI

• Structural information:
  • Protein Domains: (32..12-)
    (/note="HD-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01175"-)
  • Interpro: IPR003607  
  • Prosite: PS51831
  • CDD: cd00077
  • PDB: 3NR1 5VXA
  • PDBsum: 3NR1 5VXA
  • STRING: ENSP00000377814
• Other Databases: GeneCards:  HDDC3  Malacards:  HDDC3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	IBA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)