• Gene id: 374569

Gene Summary

• Gene Symbol: ASPG   Gene   UCSC   Ensembl
• Aliases: C14orf76, GPA/WT, LYSOLP
• Gene name: asparaginase
• Alternate names: 60 kDa lysophospholipase, asparaginase homolog, lysophospholipase-transacylase, wild-type L-asparaginase,
• Gene location: 14q32.33 (104085657: 104115581)     Exons: 20     NC_000014.9

Protein Summary

• Protein general information: Q86U10  
  • Name: 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase transacylase) [Includes: L asparaginase (EC 3.5.1.1) (L asparagine amidohydrolase); 1 alkyl 2 acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet activating factor acetylhydrolase)
  • Length: 573  
  • Mass: 60883
• Sequence:

  MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDTLVLPPASRNQRILYT
  VLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMAFAASMLSFMLENLQKTVILTGAQVPIHALW
  SDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGK
  AGLVVHSSMEQDVGLLRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCL
  QGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEMTPPSVEERRPSLQGN
  TLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAV
  TMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA
  DLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEVLPGV

• Structural information:
  • Protein Domains: (9..35-)
    (/note="Asparaginase/glutaminase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01068"-)
  • Interpro: IPR002110  IPR020683  IPR036770  IPR006033  IPR036152   IPR006034  IPR027475  IPR040919  IPR027473  IPR041725  IPR027474  IPR037152  
  • Prosite: PS50297 PS50088 PS00917 PS51732
  • CDD: cd08963
  • STRING: ENSP00000450040
• Other Databases: GeneCards:  ASPG  Malacards:  ASPG

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006530	asparagine catabolic process	IBA	biological process
GO:0004067	asparaginase activity	IBA	molecular function
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	ISS	molecular function
GO:0004622	lysophospholipase activity	ISS	molecular function
GO:0004067	asparaginase activity	IEA	molecular function
GO:0006520	cellular amino acid metabolic process	IEA	biological process
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016042	lipid catabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0004622	lysophospholipase activity	IEA	molecular function
GO:0102545	phosphatidyl phospholipase B activity	IEA	molecular function
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	IEA	molecular function
GO:0004067	asparaginase activity	IEA	molecular function
GO:0004067	asparaginase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0008652	cellular amino acid biosynthetic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray