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Gene id 3725
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol JUN   Gene   UCSC   Ensembl
Aliases AP-1, AP1, c-Jun, cJUN, p39
Gene name Jun proto-oncogene, AP-1 transcription factor subunit
Alternate names transcription factor AP-1, Jun activation domain binding protein, activator protein 1, enhancer-binding protein AP1, jun oncogene, proto-oncogene c-Jun, proto-oncogene cJun, v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma virus 17 oncogene homolog,
Gene location 1p32.1 (58784046: 58780790)     Exons: 1     NC_000001.11
Gene summary(Entrez) This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless
OMIM 165160

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa00500Starch and sucrose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00620Pyruvate metabolism
hsa00562Inositol phosphate metabolism
hsa00140Steroid hormone biosynthesis
hsa00230Purine metabolism
hsa00230Purine metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00220Arginine biosynthesis
hsa00480Glutathione metabolism
hsa00480Glutathione metabolism
hsa00480Glutathione metabolism
hsa00511Other glycan degradation
hsa00750Vitamin B6 metabolism
hsa00670One carbon pool by folate
hsa00670One carbon pool by folate
hsa00830Retinol metabolism
hsa00983Drug metabolism - other enzymes
hsa03022Basal transcription factors
hsa03040Spliceosome
hsa03013RNA transport
hsa04141Protein processing in endoplasmic reticulum
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
hsa03420Nucleotide excision repair
hsa03440Homologous recombination
hsa03440Homologous recombination
hsa03460Fanconi anemia pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04015Rap1 signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04012ErbB signaling pathway
hsa04012ErbB signaling pathway
hsa04012ErbB signaling pathway
hsa04012ErbB signaling pathway
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04350TGF-beta signaling pathway
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04371Apelin signaling pathway
hsa04371Apelin signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04630JAK-STAT signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04668TNF signaling pathway
hsa04024cAMP signaling pathway
hsa04137Mitophagy - animal
hsa04210Apoptosis
hsa04510Focal adhesion
hsa04530Tight junction
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04625C-type lectin receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04658Th1 and Th2 cell differentiation
hsa04659Th17 cell differentiation
hsa04657IL-17 signaling pathway
hsa04662B cell receptor signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04921Oxytocin signaling pathway
hsa04926Relaxin signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04380Osteoclast differentiation
hsa05200Pathways in cancer
hsa05203Viral carcinogenesis
hsa05231Choline metabolism in cancer
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05224Breast cancer
hsa05323Rheumatoid arthritis
hsa05321Inflammatory bowel disease
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05418Fluid shear stress and atherosclerosis
hsa04932Non-alcoholic fatty liver disease
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05135Yersinia infection
hsa05133Pertussis
hsa05166Human T-cell leukemia virus 1 infection
hsa05170Human immunodeficiency virus 1 infection
hsa05162Measles
hsa05161Hepatitis B
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05169Epstein-Barr virus infection
hsa05140Leishmaniasis
hsa05142Chagas disease
hsa01522Endocrine resistance

Diseases

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Associated diseases References
Cancer GAD: 18950845
Crohn's disease GAD: 19249008
Endometriosis INFBASE: 15501904
Preeclampsia INFBASE: 24931237
Polycystic ovary syndrome (PCOS) INFBASE: 22344199
Female infertility INFBASE: 22344199
Male factor infertility MIK: 17934699
Spermatogenesis defects MIK: 17934699
Female infertility INFBASE: 24931237
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Hypospadias MIK: 24778562
Hypospermatogenesis MIK: 28361989
Regulation of spermatogenesis MIK: 26753906
Male infertility MIK: 26753906
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26753906 Regulation
of sperma
togenesis,
Male infe
rtility
27 patients wit
h obstructive a
zoospermia
 Male infertility
Show abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28361989 Hyposperma
togenesis
6 (3 controls,
3 Klienfelter s
yndrome
 Male infertility Microarray
 Show abstract
24778562 Hypospadia
s
13 (5 controls,
8 cases)
 Male infertility Microarray
 Show abstract