• Gene id: 3676

Gene Summary

• Gene Symbol: ITGA4   Gene   UCSC   Ensembl
• Aliases: CD49D, IA4
• Gene name: integrin subunit alpha 4
• Alternate names: integrin alpha-4, 269C wild type, CD49 antigen-like family member D, VLA-4 subunit alpha, alpha 4 subunit of VLA-4 receptor, antigen CD49D, alpha-4 subunit of VLA-4 receptor, integrin alpha-IV, very late activation protein 4 receptor, alpha 4 subunit,
• Gene location: 2q31.3 (181456891: 181538927)     Exons: 29     NC_000001.11
• Gene summary(Entrez): The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is
• OMIM: 192975

Protein Summary

• Protein general information: P13612  
  • Name: Integrin alpha 4 (CD49 antigen like family member D) (Integrin alpha IV) (VLA 4 subunit alpha) (CD antigen CD49d)
  • Length: 1032  
  • Mass: 114,900
• Sequence:

  MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTAN
  WLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKN
  IFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSL
  FVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
  KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNL
  GDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAV
  GAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNR
  KAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
  PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTL
  HVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATC
  ENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVE
  IMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
  LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRY
  FTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

• Structural information:
  • Interpro: IPR013517  IPR013519  IPR000413  IPR013649  IPR018184   IPR028994  IPR032695  
  • Prosite: PS51470 PS00242
  • PDB: 3V4P 3V4V 4HKC 5C7Z 5FPI
  • PDBsum: 3V4P 3V4V 4HKC 5C7Z 5FPI
  • DIP: 34971
  • STRING: ENSP00000380227
• Other Databases: GeneCards:  ITGA4  Malacards:  ITGA4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001968	fibronectin binding	IEA	molecular function
GO:0003366	cell-matrix adhesion involved in ameboidal cell migration	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007159	leukocyte cell-cell adhesion	IDA	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0007229	integrin-mediated signaling pathway	IEA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0015026	coreceptor activity	TAS	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0030183	B cell differentiation	IC	biological process
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0034113	heterotypic cell-cell adhesion	IMP	biological process
GO:0034446	substrate adhesion-dependent cell spreading	IMP	biological process
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0035987	endodermal cell differentiation	IEP	biological process
GO:0043113	receptor clustering	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0050776	regulation of immune response	TAS	biological process
GO:0050839	cell adhesion molecule binding	IPI	molecular function
GO:0050839	cell adhesion molecule binding	IMP	molecular function
GO:0050900	leukocyte migration	TAS	biological process
GO:0050901	leukocyte tethering or rolling	IMP	biological process
GO:0050904	diapedesis	IEA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071345	cellular response to cytokine stimulus	IEA	biological process
GO:0090074	negative regulation of protein homodimerization activity	IDA	biological process
GO:0098657	import into cell	IEA	biological process
GO:1903238	positive regulation of leukocyte tethering or rolling	IEA	biological process
GO:1990405	protein antigen binding	IEA	molecular function
GO:1990771	clathrin-dependent extracellular exosome endocytosis	IEA	biological process
GO:2000406	positive regulation of T cell migration	IEA	biological process
GO:0019960	C-X3-C chemokine binding	IDA	molecular function
GO:0001968	fibronectin binding	IEA	molecular function
GO:0002687	positive regulation of leukocyte migration	IEA	biological process
GO:0003366	cell-matrix adhesion involved in ameboidal cell migration	IMP	biological process
GO:0003823	antigen binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0007155	cell adhesion	IEA	biological process
GO:0007159	leukocyte cell-cell adhesion	IDA	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0007229	integrin-mediated signaling pathway	IEA	biological process
GO:0008305	integrin complex	IEA	cellular component
GO:0009986	cell surface	IEA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0015026	coreceptor activity	TAS	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030183	B cell differentiation	IC	biological process
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0034113	heterotypic cell-cell adhesion	IMP	biological process
GO:0034446	substrate adhesion-dependent cell spreading	IMP	biological process
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0035987	endodermal cell differentiation	IEP	biological process
GO:0043113	receptor clustering	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0050776	regulation of immune response	TAS	biological process
GO:0050839	cell adhesion molecule binding	IEA	molecular function
GO:0050839	cell adhesion molecule binding	IPI	molecular function
GO:0050839	cell adhesion molecule binding	IMP	molecular function
GO:0050900	leukocyte migration	TAS	biological process
GO:0050901	leukocyte tethering or rolling	IMP	biological process
GO:0050904	diapedesis	IEA	biological process
GO:0070062	extracellular exosome	IEA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071345	cellular response to cytokine stimulus	IEA	biological process
GO:0090074	negative regulation of protein homodimerization activity	IDA	biological process
GO:0098657	import into cell	IEA	biological process
GO:1903039	positive regulation of leukocyte cell-cell adhesion	IEA	biological process
GO:1903238	positive regulation of leukocyte tethering or rolling	IEA	biological process
GO:1990405	protein antigen binding	IEA	molecular function
GO:1990771	clathrin-dependent extracellular exosome endocytosis	IEA	biological process
GO:2000406	positive regulation of T cell migration	IEA	biological process
GO:0019960	C-X3-C chemokine binding	IDA	molecular function
GO:0003366	cell-matrix adhesion involved in ameboidal cell migration	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0007159	leukocyte cell-cell adhesion	IDA	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0007160	cell-matrix adhesion	IMP	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0015026	coreceptor activity	TAS	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0030183	B cell differentiation	IC	biological process
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0034113	heterotypic cell-cell adhesion	IMP	biological process
GO:0034446	substrate adhesion-dependent cell spreading	IMP	biological process
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0034669	integrin alpha4-beta7 complex	IDA	cellular component
GO:0035987	endodermal cell differentiation	IEP	biological process
GO:0043113	receptor clustering	IMP	biological process
GO:0050776	regulation of immune response	TAS	biological process
GO:0050839	cell adhesion molecule binding	IPI	molecular function
GO:0050839	cell adhesion molecule binding	IMP	molecular function
GO:0050900	leukocyte migration	TAS	biological process
GO:0050901	leukocyte tethering or rolling	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0090074	negative regulation of protein homodimerization activity	IDA	biological process
GO:0019960	C-X3-C chemokine binding	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa04512	ECM-receptor interaction
hsa04514	Cell adhesion molecules
hsa04510	Focal adhesion
hsa04810	Regulation of actin cytoskeleton
hsa04640	Hematopoietic cell lineage
hsa04670	Leukocyte transendothelial migration
hsa04672	Intestinal immune network for IgA production
hsa05410	Hypertrophic cardiomyopathy
hsa05412	Arrhythmogenic right ventricular cardiomyopathy
hsa05414	Dilated cardiomyopathy
hsa05135	Yersinia infection
hsa05165	Human papillomavirus infection
hsa05140	Leishmaniasis

Diseases

Associated diseases	References
Cancer	GAD: 19074885
Cancer (leukemia)	GAD: 19074885
Multiple sclerosis	GAD: 17609118
Multiple sclerosis	GAD: 19604093
Multiple sclerosis	GAD: 17609118
Celiac disease	GAD: 20190752
Stroke	GAD: 12686501
Stroke	GAD: 12686501
Autism	GAD: 18846500
Autism	GAD: 19259978
Female infertility	INFBASE: 19579970
Recurrent implantation failure (RIF)	INFBASE: 23755950
Fertilizing defects	INFBASE: 7540183
Defective uterine receptivity	INFBASE: 10641167
Adenomyosis	INFBASE: 9392916
Endometriosis	INFBASE: 7691869
Primary unexplained infertility	INFBASE: 7851583
Recurrent pregnancy loss (RPL)	INFBASE: 14666169
Unexplained infertility	INFBASE: 7851583
Male factor infertility	MIK: 7540183
Teratozoospermia	MIK: 8270377
Fertilizing defects	MIK: 7540183
Female infertility	INFBASE: 16433835
Fertilizing ability	MIK: 7540183
Teratozoospermia	MIK: 8270377

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
8270377	Teratozoospermia				Male infertility	VLA alpha 4 VLA alpha 5 and laminin
7540183	Fertilizing ability			50 semen samples	Male infertility	alpha 4 alpha 5 beta 1-integrin and alpha 6