• Gene id: 3630

Gene Summary

• Gene Symbol: INS   Gene   UCSC   Ensembl
• Aliases: IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
• Gene name: insulin
• Alternate names: insulin, preproinsulin, proinsulin,
• Gene location: 11p15.5 (2161208: 2159778)     Exons: 3     NC_000011.10
• Gene summary(Entrez): This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A c
• OMIM: 147671

Protein Summary

• Protein general information: P01308  
  • Name: Insulin [Cleaved into: Insulin B chain; Insulin A chain]
  • Length: 110  
  • Mass: 11981
• Sequence:

  MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAG
  SLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

• Structural information:
  • Interpro: IPR004825  IPR016179  IPR036438  IPR022353  IPR022352  
  • Prosite: PS00262
  • PDB: 1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G5
  • PDBsum: 1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G5
  • DIP: 6024
  • STRING: ENSP00000380432
• Other Databases: GeneCards:  INS  Malacards:  INS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1990535	neuron projection maintenance	IGI	biological process
GO:1903427	negative regulation of reactive oxygen species biosynthetic process	IGI	biological process
GO:1903076	regulation of protein localization to plasma membrane	IGI	biological process
GO:1902952	positive regulation of dendritic spine maintenance	IGI	biological process
GO:1900273	positive regulation of long-term synaptic potentiation	TAS	biological process
GO:0048167	regulation of synaptic plasticity	TAS	biological process
GO:0050890	cognition	TAS	biological process
GO:2000252	negative regulation of feeding behavior	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005179	hormone activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0005179	hormone activity	IEA	molecular function
GO:0050995	negative regulation of lipid catabolic process	IMP	biological process
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	TAS	biological process
GO:0030133	transport vesicle	TAS	cellular component
GO:0030133	transport vesicle	TAS	cellular component
GO:0030133	transport vesicle	TAS	cellular component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	cellular component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	cellular component
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0008286	insulin receptor signaling pathway	TAS	biological process
GO:0031904	endosome lumen	TAS	cellular component
GO:0031904	endosome lumen	TAS	cellular component
GO:0031904	endosome lumen	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005158	insulin receptor binding	IDA	molecular function
GO:0005179	hormone activity	IC	molecular function
GO:0005158	insulin receptor binding	IPI	molecular function
GO:0005159	insulin-like growth factor receptor binding	IPI	molecular function
GO:0005179	hormone activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	biological process
GO:0033861	negative regulation of NAD(P)H oxidase activity	IDA	biological process
GO:0042060	wound healing	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0045821	positive regulation of glycolytic process	IDA	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	biological process
GO:0060266	negative regulation of respiratory burst involved in inflammatory response	IDA	biological process
GO:0060267	positive regulation of respiratory burst	IDA	biological process
GO:0030335	positive regulation of cell migration	ISS	biological process
GO:0031954	positive regulation of protein autophosphorylation	ISS	biological process
GO:0032270	positive regulation of cellular protein metabolic process	IMP	biological process
GO:0042593	glucose homeostasis	IMP	biological process
GO:0045597	positive regulation of cell differentiation	NAS	biological process
GO:0045821	positive regulation of glycolytic process	IMP	biological process
GO:0045922	negative regulation of fatty acid metabolic process	IMP	biological process
GO:0050995	negative regulation of lipid catabolic process	NAS	biological process
GO:0090277	positive regulation of peptide hormone secretion	TAS	biological process
GO:0090336	positive regulation of brown fat cell differentiation	TAS	biological process
GO:0002674	negative regulation of acute inflammatory response	IDA	biological process
GO:0006953	acute-phase response	IDA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0022898	regulation of transmembrane transporter activity	IDA	biological process
GO:0032148	activation of protein kinase B activity	IDA	biological process
GO:0032880	regulation of protein localization	IDA	biological process
GO:0043410	positive regulation of MAPK cascade	IDA	biological process
GO:0045725	positive regulation of glycogen biosynthetic process	IDA	biological process
GO:0045840	positive regulation of mitotic nuclear division	IDA	biological process
GO:0046326	positive regulation of glucose import	IDA	biological process
GO:0046628	positive regulation of insulin receptor signaling pathway	IDA	biological process
GO:0050709	negative regulation of protein secretion	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0008286	insulin receptor signaling pathway	IDA	biological process
GO:0006355	regulation of transcription, DNA-templated	NAS	biological process
GO:0006521	regulation of cellular amino acid metabolic process	IMP	biological process
GO:0030307	positive regulation of cell growth	NAS	biological process
GO:0045721	negative regulation of gluconeogenesis	NAS	biological process
GO:0045818	negative regulation of glycogen catabolic process	IMP	biological process
GO:0045861	negative regulation of proteolysis	IMP	biological process
GO:0046889	positive regulation of lipid biosynthetic process	NAS	biological process
GO:0055089	fatty acid homeostasis	IMP	biological process
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NAS	biological process
GO:1900182	positive regulation of protein localization to nucleus	IDA	biological process
GO:0043410	positive regulation of MAPK cascade	IDA	biological process
GO:0010628	positive regulation of gene expression	IGI	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0050715	positive regulation of cytokine secretion	IDA	biological process
GO:0046631	alpha-beta T cell activation	IDA	biological process
GO:0007267	cell-cell signaling	IC	biological process
GO:0005576	extracellular region	IC	cellular component
GO:0050708	regulation of protein secretion	IDA	biological process
GO:0045840	positive regulation of mitotic nuclear division	IDA	biological process
GO:0046628	positive regulation of insulin receptor signaling pathway	IDA	biological process
GO:0042177	negative regulation of protein catabolic process	IDA	biological process
GO:0005158	insulin receptor binding	IDA	molecular function
GO:0046326	positive regulation of glucose import	IDA	biological process
GO:0010750	positive regulation of nitric oxide mediated signal transduction	IDA	biological process
GO:0010750	positive regulation of nitric oxide mediated signal transduction	IMP	biological process
GO:0051000	positive regulation of nitric-oxide synthase activity	NAS	biological process
GO:0005179	hormone activity	NAS	molecular function
GO:0002020	protease binding	IPI	molecular function
GO:0097755	positive regulation of blood vessel diameter	NAS	biological process
GO:0097756	negative regulation of blood vessel diameter	NAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0046326	positive regulation of glucose import	IMP	biological process
GO:0046628	positive regulation of insulin receptor signaling pathway	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa05010	Alzheimer disease
hsa04151	PI3K-Akt signaling pathway
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04150	mTOR signaling pathway
hsa04072	Phospholipase D signaling pathway
hsa04140	Autophagy - animal
hsa04932	Non-alcoholic fatty liver disease
hsa04910	Insulin signaling pathway
hsa04114	Oocyte meiosis
hsa04152	AMPK signaling pathway
hsa04068	FoxO signaling pathway
hsa04931	Insulin resistance
hsa04066	HIF-1 signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04911	Insulin secretion
hsa04211	Longevity regulating pathway
hsa05215	Prostate cancer
hsa04917	Prolactin signaling pathway
hsa04213	Longevity regulating pathway - multiple species
hsa04930	Type II diabetes mellitus
hsa04923	Regulation of lipolysis in adipocytes
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04913	Ovarian steroidogenesis
hsa04940	Type I diabetes mellitus
hsa04950	Maturity onset diabetes of the young

Diseases

Associated diseases	References
Type 1 diabetes mellitus	KEGG:H00408
Maturity onset diabetes of the young	KEGG:H00410
Permanent neonatal diabetes mellitus	KEGG:H00512
Type 1 diabetes mellitus	KEGG:H00408
Maturity onset diabetes of the young	KEGG:H00410
Permanent neonatal diabetes mellitus	KEGG:H00512
Prostate cancer	PMID:27599544
Gestational diabetes	PMID:19269197
pancreatic cancer	PMID:19152242
Hyperuricemia	PMID:19033255
Hyperinsulinism	PMID:9667398
pancreatic ductal carcinoma	PMID:19571666
Insulinoma	PMID:2565624
Insulinoma	PMID:8175958
Osteoarthritis	PMID:2290165
Diabetic retinopathy	PMID:22046295
diabetes mellitus	PMID:20034470
diabetes mellitus	PMID:18451997
diabetes mellitus	PMID:19537357
diabetes mellitus	PMID:17855560
type 2 diabetes mellitus	PMID:3322910
type 2 diabetes mellitus	PMID:1569197
Fatty liver disease	PMID:18713300
type 1 diabetes mellitus	PMID:18824271
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq